Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita; Tatsunori Yamashita; Koji Yamada; Hirofumi Tachibana

doi:10.1016/j.febslet.2009.12.044

Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita, Tatsunori Yamashita, Koji Yamada, Hirofumi Tachibana

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

Original language	English
Pages (from-to)	775-779
Number of pages	5
Journal	FEBS Letters
Volume	584
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2009.12.044
Publication status	Published - Feb 2010

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain",

abstract = "Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.",

author = "Shuya Yamashita and Tatsunori Yamashita and Koji Yamada and Hirofumi Tachibana",

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AU - Yamashita, Shuya

AU - Yamashita, Tatsunori

AU - Yamada, Koji

AU - Tachibana, Hirofumi

PY - 2010/2

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N2 - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

AB - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

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