Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita, Tatsunori Yamashita, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

Original languageEnglish
Pages (from-to)775-779
Number of pages5
JournalFEBS Letters
Volume584
Issue number4
DOIs
Publication statusPublished - Feb 1 2010

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Type I Interleukin-4 Receptors
Flavones
Interleukin-4
Interleukin-1
Immunoglobulin E
Janus Kinase 3
STAT6 Transcription Factor
Immunoglobulin Class Switching
Phosphorylation
Interleukins
Transcription
Interleukin-2
B-Lymphocytes
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. / Yamashita, Shuya; Yamashita, Tatsunori; Yamada, Koji; Tachibana, Hirofumi.

In: FEBS Letters, Vol. 584, No. 4, 01.02.2010, p. 775-779.

Research output: Contribution to journalArticle

Yamashita, Shuya ; Yamashita, Tatsunori ; Yamada, Koji ; Tachibana, Hirofumi. / Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. In: FEBS Letters. 2010 ; Vol. 584, No. 4. pp. 775-779.
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