Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita, Tatsunori Yamashita, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

Original languageEnglish
Pages (from-to)775-779
Number of pages5
JournalFEBS Letters
Volume584
Issue number4
DOIs
Publication statusPublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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