Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita, Tatsunori Yamashita, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

Original languageEnglish
Pages (from-to)775-779
Number of pages5
JournalFEBS Letters
Volume584
Issue number4
DOIs
Publication statusPublished - Feb 1 2010

Fingerprint

Type I Interleukin-4 Receptors
Flavones
Interleukin-4
Interleukin-1
Immunoglobulin E
Janus Kinase 3
STAT6 Transcription Factor
Immunoglobulin Class Switching
Phosphorylation
Interleukins
Transcription
Interleukin-2
B-Lymphocytes
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. / Yamashita, Shuya; Yamashita, Tatsunori; Yamada, Koji; Tachibana, Hirofumi.

In: FEBS Letters, Vol. 584, No. 4, 01.02.2010, p. 775-779.

Research output: Contribution to journal › Article

Yamashita, S, Yamashita, T, Yamada, K & Tachibana, H 2010, 'Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain', FEBS Letters, vol. 584, no. 4, pp. 775-779. https://doi.org/10.1016/j.febslet.2009.12.044
Yamashita S, Yamashita T, Yamada K, Tachibana H. Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. FEBS Letters. 2010 Feb 1;584(4):775-779. https://doi.org/10.1016/j.febslet.2009.12.044
Yamashita, Shuya ; Yamashita, Tatsunori ; Yamada, Koji ; Tachibana, Hirofumi. / Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. In: FEBS Letters. 2010 ; Vol. 584, No. 4. pp. 775-779.
@article{38e3fed6756d4497b2e99549c124d64f,
title = "Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain",
abstract = "Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.",
author = "Shuya Yamashita and Tatsunori Yamashita and Koji Yamada and Hirofumi Tachibana",
year = "2010",
month = "2",
day = "1",
doi = "10.1016/j.febslet.2009.12.044",
language = "English",
volume = "584",
pages = "775--779",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

AU - Yamashita, Shuya

AU - Yamashita, Tatsunori

AU - Yamada, Koji

AU - Tachibana, Hirofumi

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

AB - Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

UR - http://www.scopus.com/inward/record.url?scp=77649270386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649270386&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2009.12.044

DO - 10.1016/j.febslet.2009.12.044

M3 - Article

C2 - 20040389

AN - SCOPUS:77649270386

VL - 584

SP - 775

EP - 779

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 4

ER -

Access to Document