Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities

Alain B. Dongmo, Tomofumi Miyamoto, Kazuko Yoshikawa, Shigenobu Arihara, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10-4 g/mL and 5-14% inhibition at 10-4 g/mL, respectively.

Original languageEnglish
Pages (from-to)1202-1207
Number of pages6
JournalPlanta Medica
Volume73
Issue number11
DOIs
Publication statusPublished - Sep 1 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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