Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10-4 g/mL and 5-14% inhibition at 10-4 g/mL, respectively.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry