Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities

Alain B. Dongmo; Tomofumi Miyamoto; Kazuko Yoshikawa; Shigenobu Arihara; Marie Aleth Lacaille-Dubois

doi:10.1055/s-2007-981596

Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities

Alain B. Dongmo, Tomofumi Miyamoto, Kazuko Yoshikawa, Shigenobu Arihara, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10^-4 g/mL and 5-14% inhibition at 10^-4 g/mL, respectively.

Original language	English
Pages (from-to)	1202-1207
Number of pages	6
Journal	Planta Medica
Volume	73
Issue number	11
DOIs	https://doi.org/10.1055/s-2007-981596
Publication status	Published - Sept 1 2007

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities",

abstract = "Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10-4 g/mL and 5-14% inhibition at 10-4 g/mL, respectively.",

author = "Dongmo, {Alain B.} and Tomofumi Miyamoto and Kazuko Yoshikawa and Shigenobu Arihara and Lacaille-Dubois, {Marie Aleth}",

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AU - Dongmo, Alain B.

AU - Miyamoto, Tomofumi

AU - Yoshikawa, Kazuko

AU - Arihara, Shigenobu

AU - Lacaille-Dubois, Marie Aleth

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10-4 g/mL and 5-14% inhibition at 10-4 g/mL, respectively.

AB - Two new flavonoids quercetin 4′-O-α-L-rhamnopyranosyl-3-O- β-D-allopyranoside (1) and apigenin 6-C-[2″-O-(E)-feruloyl-β-D- glucopyranosyl]-8-C-β-glucopyranoside (2), along with the known isorhamnetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-0-α-L- rhamnopyranosyl-(1→4)-β-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10-4 g/mL and 5-14% inhibition at 10-4 g/mL, respectively.

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Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities

Abstract

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