Flow visualization through particle image velocimetry in realistic model of rhesus monkey's upper airway

Ji Woong Kim, Nguyen Lu Phuong, Shin ichiro Aramaki, Kazuhide Ito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Studies concerning inhalation toxicology and respiratory drug-delivery systems require biological testing involving experiments performed on animals. Particle image velocimetry (PIV) is an effective in vitro technique that reveals detailed inhalation flow patterns, thereby assisting analyses of inhalation exposure to various substances. A realistic model of a rhesus-monkey upper airway was developed to investigate flow patterns in its oral and nasal cavities through PIV experiments performed under steady-state constant inhalation conditions at various flow rates—4, 10, and 20 L/min. Flow rate of the fluid passing through the inlet into the trachea was measured to obtain characteristic flow mechanisms, and flow phenomena in the model were confirmed via characterized flow fields. It was observed that increase in flow rate leads to constant velocity profiles in upper and lower trachea regions. It is expected that the results of this study would contribute to future validation of studies aimed at developing in silico models, especially those involving computational fluid dynamic (CFD) analysis.

Original languageEnglish
Pages (from-to)16-27
Number of pages12
JournalRespiratory Physiology and Neurobiology
Volume251
DOIs
Publication statusPublished - May 1 2018

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Rheology
Macaca mulatta
Inhalation
Trachea
Inhalation Exposure
Validation Studies
Nasal Cavity
Hydrodynamics
Drug Delivery Systems
Computer Simulation
Toxicology
Mouth

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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Flow visualization through particle image velocimetry in realistic model of rhesus monkey's upper airway. / Kim, Ji Woong; Phuong, Nguyen Lu; Aramaki, Shin ichiro; Ito, Kazuhide.

In: Respiratory Physiology and Neurobiology, Vol. 251, 01.05.2018, p. 16-27.

Research output: Contribution to journalArticle

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