Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible: Clinical and pathological evaluation

Daigo Yoshiga, Masaaki Sasaguri, Kou Matsuo, Sei Yoshida, Masataka Uehara, Manabu Habu, Kazuya Haraguchi, Tatsurou Tanaka, Yasuhiro Morimoto, Izumi Yoshioka, Kazuhiro Tominaga

Research output: Contribution to journalArticle

Abstract

Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope®). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope®was handy and useful to determine the border between DCSO lesion andhealthybone. The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope®offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.

Original languageEnglish
Article number52268
Pages (from-to)e548-e551
JournalJournal of Clinical and Experimental Dentistry
Volume7
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Mandible
Minocycline
Fibula
Free Tissue Flaps
Fluorescence
Bone and Bones
Mandibular Osteotomy
Inflammation
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible : Clinical and pathological evaluation. / Yoshiga, Daigo; Sasaguri, Masaaki; Matsuo, Kou; Yoshida, Sei; Uehara, Masataka; Habu, Manabu; Haraguchi, Kazuya; Tanaka, Tatsurou; Morimoto, Yasuhiro; Yoshioka, Izumi; Tominaga, Kazuhiro.

In: Journal of Clinical and Experimental Dentistry, Vol. 7, No. 4, 52268, 01.01.2015, p. e548-e551.

Research output: Contribution to journalArticle

Yoshiga, Daigo ; Sasaguri, Masaaki ; Matsuo, Kou ; Yoshida, Sei ; Uehara, Masataka ; Habu, Manabu ; Haraguchi, Kazuya ; Tanaka, Tatsurou ; Morimoto, Yasuhiro ; Yoshioka, Izumi ; Tominaga, Kazuhiro. / Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible : Clinical and pathological evaluation. In: Journal of Clinical and Experimental Dentistry. 2015 ; Vol. 7, No. 4. pp. e548-e551.
@article{07e5e89931af42e883e33d89f07fc101,
title = "Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible: Clinical and pathological evaluation",
abstract = "Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope{\circledR}). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope{\circledR}was handy and useful to determine the border between DCSO lesion andhealthybone. The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope{\circledR}offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.",
author = "Daigo Yoshiga and Masaaki Sasaguri and Kou Matsuo and Sei Yoshida and Masataka Uehara and Manabu Habu and Kazuya Haraguchi and Tatsurou Tanaka and Yasuhiro Morimoto and Izumi Yoshioka and Kazuhiro Tominaga",
year = "2015",
month = "1",
day = "1",
doi = "10.4317/jced.52268",
language = "English",
volume = "7",
pages = "e548--e551",
journal = "Journal of Clinical and Experimental Dentistry",
issn = "1989-5488",
publisher = "Medicina Oral S.L",
number = "4",

}

TY - JOUR

T1 - Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible

T2 - Clinical and pathological evaluation

AU - Yoshiga, Daigo

AU - Sasaguri, Masaaki

AU - Matsuo, Kou

AU - Yoshida, Sei

AU - Uehara, Masataka

AU - Habu, Manabu

AU - Haraguchi, Kazuya

AU - Tanaka, Tatsurou

AU - Morimoto, Yasuhiro

AU - Yoshioka, Izumi

AU - Tominaga, Kazuhiro

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope®). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope®was handy and useful to determine the border between DCSO lesion andhealthybone. The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope®offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.

AB - Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope®). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope®was handy and useful to determine the border between DCSO lesion andhealthybone. The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope®offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.

UR - http://www.scopus.com/inward/record.url?scp=84946411517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946411517&partnerID=8YFLogxK

U2 - 10.4317/jced.52268

DO - 10.4317/jced.52268

M3 - Article

AN - SCOPUS:84946411517

VL - 7

SP - e548-e551

JO - Journal of Clinical and Experimental Dentistry

JF - Journal of Clinical and Experimental Dentistry

SN - 1989-5488

IS - 4

M1 - 52268

ER -