Fluorescence sensory system orchestrated by molecular self-assembly

Takao Noguchi, Daisuke Yoshihara, Seiji Shinkai

Research output: Contribution to journalReview article

Abstract

Self-assembly has been utilized for the spontaneous formation of nanoarchitectures. Therein, a small change in the molecular structure dramatically alters the resulting macroscopic self-assembly morphologies and the consequent material properties. This macroscopic expression of the small initial difference via self-assembly can be alternatively regarded as precise translation of molecular structural information. In this contribution, we offer a novel molecular recognition concept utilizing self-assembly phenomena. A small difference in guest structures affords distinctly different self-assembly modes of fluorescent (FL) chemosensors, leading to their sensory responses characteristic to the guest structures. Thus, self-assembly has now been utilized as a FL sensory system for molecular recognition, particularly, of biologically important molecules and polymers. Here, we demonstrate that the integral magnitude of binding mechanism, self-assembly, and FL response realizes (i) selective FL detection of ATP, (ii) FL differentiation of dicarboxylates and keto-acids, and (iii) unexpectedly selective FL sensing of hyaluronic acid among glycosaminoglycans.

Original languageEnglish
Pages (from-to)49-61
Number of pages13
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Self assembly
Fluorescence
Molecular recognition
Keto Acids
Hyaluronic Acid
Glycosaminoglycans
Molecular structure
Materials properties
Polymers
Adenosine Triphosphate
Molecules

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Fluorescence sensory system orchestrated by molecular self-assembly. / Noguchi, Takao; Yoshihara, Daisuke; Shinkai, Seiji.

In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Vol. 75, No. 1, 01.01.2017, p. 49-61.

Research output: Contribution to journalReview article

Noguchi, Takao ; Yoshihara, Daisuke ; Shinkai, Seiji. / Fluorescence sensory system orchestrated by molecular self-assembly. In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2017 ; Vol. 75, No. 1. pp. 49-61.
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