Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration

Shinji Kamakura, Takashi Kumagai, Yoshitomo Honda, Takahisa Anada, Keiichi Sasaki, Hidetoshi Shimauchi, Osamu Suzuki

Research output: Contribution to journalArticle

Abstract

It has been shown that fluoride ions enhance OCP hydrolysis into Ca-deficient apatite and that fluoridation in hydroxyapatite (HA) affects osteoblast activity. The present study was designed to investigate whether fluoridated Ca-deficient apatite (F-HA) formed via OCP enhances bone regeneration. F-HA was obtained through hydrolysis of the OCP in a solution containing 2 ppm fluoride at 37°C and pH 7.4. A standardized critical-sized defect was made in the rat calvarium, and granules of F-HA were implanted into the defect. Five rats from each group were fixed through four to twelve weeks after implantation. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) confirmed that F-HA corresponded well to apatite structure. In week four, new bone matrix was formed around F-HA. In week twelve of F-HA group, newly formed bone matrix was more abundant, whereas the implanted F-HA was unresorbed and still remained. A statistical analysis in week twelve showed that the newly formed bone in the defect with F-HA was higher than that with untreated group. The fact that new bone was directly formed on F-HA implant suggests F-HA formed via OCP could be used as a bone substitute material.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
Publication statusPublished - Apr 5 2006
Externally publishedYes

Fingerprint

Apatites
Apatite
Durapatite
Hydroxyapatite
Bone
Phosphates
Fluorides
Defects
Rats
Hydrolysis
Fluoridation
octacalcium phosphate
Bone Substitutes
Osteoblasts
Fourier transform infrared spectroscopy
Statistical methods
Ions

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Kamakura, S., Kumagai, T., Honda, Y., Anada, T., Sasaki, K., Shimauchi, H., & Suzuki, O. (2006). Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration. Key Engineering Materials, 309-311 I, 137-140.

Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration. / Kamakura, Shinji; Kumagai, Takashi; Honda, Yoshitomo; Anada, Takahisa; Sasaki, Keiichi; Shimauchi, Hidetoshi; Suzuki, Osamu.

In: Key Engineering Materials, Vol. 309-311 I, 05.04.2006, p. 137-140.

Research output: Contribution to journalArticle

Kamakura, S, Kumagai, T, Honda, Y, Anada, T, Sasaki, K, Shimauchi, H & Suzuki, O 2006, 'Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration', Key Engineering Materials, vol. 309-311 I, pp. 137-140.
Kamakura S, Kumagai T, Honda Y, Anada T, Sasaki K, Shimauchi H et al. Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration. Key Engineering Materials. 2006 Apr 5;309-311 I:137-140.
Kamakura, Shinji ; Kumagai, Takashi ; Honda, Yoshitomo ; Anada, Takahisa ; Sasaki, Keiichi ; Shimauchi, Hidetoshi ; Suzuki, Osamu. / Fluoridated Ca-deficient apatite formed via octacalcium phosphate enhances bone regeneration. In: Key Engineering Materials. 2006 ; Vol. 309-311 I. pp. 137-140.
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