Fluorine electron double resonance imaging for 19F MRI in low magnetic fields

Ramachandran Murugesan, Sean English, Koen Reijnders, Ken-Ichi Yamada, John A. Cook, James B. Mitchell, Sankaran Subramanian, Murali C. Krishna

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This work demonstrates the feasibility of generating fluorine NMR images at a very low magnetic field of 0.015 T by making use of the Overhauser enhancement of 19F NMR signal brought about by a stable, water-soluble, narrow-line paramagnetic contrast agent. The enhancement in the 19F NMR images depends on the concentration of the single electron contrast agent, the pO2, and the electron paramagnetic resonance (EPR) irradiation power. The applicability of this technique for 19F NMR imaging is demonstrated with phantom samples, where a time resolution of 4-10 min is achieved. Proton electron double resonance imaging (PEDRI) and fluorine electron double resonance imaging (FEDRI) images were also obtained from rat kidneys ex vivo, perfused with 10 mM Oxo63 and 10 M trifluoroacetic acid. The spatial and temporal resolutions of these images are comparable to those obtained at magnetic fields 2-3 orders of magnitude larger. Constant NMR frequency (628 kHz) operation permits both FEDRI and PEDRI of identical slices without removing the object under investigation. This feasibility of coregistration of proton-based anatomical PEDRI image with physiological FEDRI image offers good potential for studying fluorine-containing tracers.

Original languageEnglish
Pages (from-to)523-529
Number of pages7
JournalMagnetic Resonance in Medicine
Volume48
Issue number3
DOIs
Publication statusPublished - Sep 1 2002

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Fluorine
Magnetic Fields
Electrons
Protons
Contrast Media
Trifluoroacetic Acid
Electron Spin Resonance Spectroscopy
Fluorine-19 Magnetic Resonance Imaging
Magnetic Resonance Imaging
Kidney
Water

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Murugesan, R., English, S., Reijnders, K., Yamada, K-I., Cook, J. A., Mitchell, J. B., ... Krishna, M. C. (2002). Fluorine electron double resonance imaging for 19F MRI in low magnetic fields. Magnetic Resonance in Medicine, 48(3), 523-529. https://doi.org/10.1002/mrm.10221

Fluorine electron double resonance imaging for 19F MRI in low magnetic fields. / Murugesan, Ramachandran; English, Sean; Reijnders, Koen; Yamada, Ken-Ichi; Cook, John A.; Mitchell, James B.; Subramanian, Sankaran; Krishna, Murali C.

In: Magnetic Resonance in Medicine, Vol. 48, No. 3, 01.09.2002, p. 523-529.

Research output: Contribution to journalArticle

Murugesan, R, English, S, Reijnders, K, Yamada, K-I, Cook, JA, Mitchell, JB, Subramanian, S & Krishna, MC 2002, 'Fluorine electron double resonance imaging for 19F MRI in low magnetic fields', Magnetic Resonance in Medicine, vol. 48, no. 3, pp. 523-529. https://doi.org/10.1002/mrm.10221
Murugesan, Ramachandran ; English, Sean ; Reijnders, Koen ; Yamada, Ken-Ichi ; Cook, John A. ; Mitchell, James B. ; Subramanian, Sankaran ; Krishna, Murali C. / Fluorine electron double resonance imaging for 19F MRI in low magnetic fields. In: Magnetic Resonance in Medicine. 2002 ; Vol. 48, No. 3. pp. 523-529.
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