Focal Adhesion Kinase in Cell-Material Interactions

Cristina González-García, Manuel Salmerón-Sánchez, Andrés J. García

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter presents a broad overview of the role of focal adhesion kinases (FAKs) in the cell-material interactions. It summarizes the effects that different material properties have on FAK signaling. The chapter first discusses the involvement of FAK in classical cellular processes at the material interface such as cell proliferation, cell migration, and mechanosensing responses. It, then reviews recent advances on the role of FAK in the generation of adhesive forces. Finally, the influence of material properties, such as chemical composition, surface nanotopography, and substrate stiffness, on FAK expression and phosphorylation is summarized, seeking to identify which surface properties trigger initial cell signaling at the material interface.

Original languageEnglish
Title of host publicationPolymers in Regenerative Medicine
Subtitle of host publicationBiomedical Applications from Nano- to Macro-Structures
Publisherwiley
Pages147-176
Number of pages30
ISBN (Electronic)9781118356692
ISBN (Print)9780470596388
DOIs
Publication statusPublished - Jan 30 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    González-García, C., Salmerón-Sánchez, M., & García, A. J. (2014). Focal Adhesion Kinase in Cell-Material Interactions. In Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures (pp. 147-176). wiley. https://doi.org/10.1002/9781118356692.ch4