Abstract
This chapter presents a broad overview of the role of focal adhesion kinases (FAKs) in the cell-material interactions. It summarizes the effects that different material properties have on FAK signaling. The chapter first discusses the involvement of FAK in classical cellular processes at the material interface such as cell proliferation, cell migration, and mechanosensing responses. It, then reviews recent advances on the role of FAK in the generation of adhesive forces. Finally, the influence of material properties, such as chemical composition, surface nanotopography, and substrate stiffness, on FAK expression and phosphorylation is summarized, seeking to identify which surface properties trigger initial cell signaling at the material interface.
| Original language | English |
|---|---|
| Title of host publication | Polymers in Regenerative Medicine |
| Subtitle of host publication | Biomedical Applications from Nano- to Macro-Structures |
| Publisher | wiley |
| Pages | 147-176 |
| Number of pages | 30 |
| ISBN (Electronic) | 9781118356692 |
| ISBN (Print) | 9780470596388 |
| DOIs | |
| Publication status | Published - Jan 30 2014 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Engineering(all)
- Chemical Engineering(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology(all)