Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood

A case report and reappraisal of the glial component in archival FCD cases

Kenta Masui, Satoshi Suzuki, Kimiaki Hashiguchi, Takato Morioka, Takashi Yoshiura, Tomio Sasaki, Toru Iwaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a rare case of focal cortical dysplasia (FCD) concurring with diffuse astrocytoma and arachnoid cyst, and also re-evaluate the glial component in archival FCD cases for the differential diagnosis of diffuse gliomas. A 7-year-old boy with a 9-month history of psychomotor seizures disclosed a hyperintense area accompanied by a cystic lesion in the left temporal lobe on MRI. The surgical specimen displayed dyslamination of the cortices and ectopic neurons in the white matter, associated with dysmorphic neurons, indicating FCD type IIA. Additionally, the lesion showed diffuse proliferation and infiltration of glial cells, immunopositive for infiltrating glioma markers (nestin, doublecortin, MAP-2e) and p53, and MIB-1 index was 2.0%. These findings indicated coexisting diffuse astrocytoma. Coexistence of diffuse glioma with FCD is unusual, but we often notice increased population of small glial cells in FCD lesions. Re-evaluation of archival FCD cases with diverse markers revealed that reactive microglia significantly proliferate in the white matter lesions. Therefore, a careful pathological assessment has to be made to define a rare case of diffuse glioma occurring in FCD.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalNeuropathology
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 1 2011

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Malformations of Cortical Development
Astrocytoma
Neuroglia
Glioma
Arachnoid Cysts
Neurons
Nestin
Microglia
Temporal Lobe
Seizures
Differential Diagnosis
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood : A case report and reappraisal of the glial component in archival FCD cases. / Masui, Kenta; Suzuki, Satoshi; Hashiguchi, Kimiaki; Morioka, Takato; Yoshiura, Takashi; Sasaki, Tomio; Iwaki, Toru.

In: Neuropathology, Vol. 31, No. 4, 01.08.2011, p. 433-439.

Research output: Contribution to journalArticle

Masui, Kenta ; Suzuki, Satoshi ; Hashiguchi, Kimiaki ; Morioka, Takato ; Yoshiura, Takashi ; Sasaki, Tomio ; Iwaki, Toru. / Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood : A case report and reappraisal of the glial component in archival FCD cases. In: Neuropathology. 2011 ; Vol. 31, No. 4. pp. 433-439.
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