Focal cortical dysplasia type IIa underlying epileptogenesis in patients with epilepsy associated with Sturge-Weber syndrome

Nobuya Murakami, Takato Morioka, Satoshi Suzuki, Kimiaki Hashiguchi, Toshiyuki Amano, Ayumi Sakata, Toru Iwaki, Tomio Sasaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In patients with epilepsy associated with Sturge-Weber syndrome (SWS), epileptogenesis has been suggested to be caused by chronic ischemia in cortical areas affected by leptomeningeal angiomatosis or by ischemia-related cortical malformations. However, this has not been fully verified electrophysiologically. We herein present two cases of SWS with medically intractable epilepsy in which the epileptogenic area involved focal cortical dysplasia (FCD) type IIa near the region of leptomeningeal angiomatosis. In both cases, the ictal-onset zones were identified by chronic subdural electrodes, and the presence of FCD type IIa was shown histopathologically. In SWS, especially in association with focal leptomeningeal angiomatosis, FCD may thus play a major role in epileptogenesis. FCD should therefore be demonstrated by the collective findings of perioperative neurophysiologic examination, anatomic and functional neuroimaging, and histopathologic examination.

Original languageEnglish
JournalEpilepsia
Volume53
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

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Sturge-Weber Syndrome
Malformations of Cortical Development
Angiomatosis
Epilepsy
Ischemia
Functional Neuroimaging
Electrodes
Stroke

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Focal cortical dysplasia type IIa underlying epileptogenesis in patients with epilepsy associated with Sturge-Weber syndrome. / Murakami, Nobuya; Morioka, Takato; Suzuki, Satoshi; Hashiguchi, Kimiaki; Amano, Toshiyuki; Sakata, Ayumi; Iwaki, Toru; Sasaki, Tomio.

In: Epilepsia, Vol. 53, No. 11, 01.11.2012.

Research output: Contribution to journalArticle

Murakami, Nobuya ; Morioka, Takato ; Suzuki, Satoshi ; Hashiguchi, Kimiaki ; Amano, Toshiyuki ; Sakata, Ayumi ; Iwaki, Toru ; Sasaki, Tomio. / Focal cortical dysplasia type IIa underlying epileptogenesis in patients with epilepsy associated with Sturge-Weber syndrome. In: Epilepsia. 2012 ; Vol. 53, No. 11.
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