TY - GEN
T1 - Force sensor probe using quartz crystal resonator having104 measurement range for mechanical characterization of spheroids
AU - Sato, Ayaka
AU - Sakuma, Shinya
AU - Kojima, Nobuhiko
AU - Tao, Fumiya
AU - Arai, Fumihito
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Recently, evaluation of biological activity of spheroids without dissolution is quite important. In this study, we focus on a force sensor for mechanical characterization of spheroids. The force sensor probe which has wide measurement range is highly required for evaluating stiffness of spheroid in medium environment because spheroid has nonlinear mechanical characteristics. Herein, we present a force sensor probe using quartz crystal resonator (QCR). The proposed force sensor probe has wide measurement range of 104 and waterproof structure. We evaluated its performance and mechanical characterization of HepG2 spheroids by using the proposed force sensor probe.
AB - Recently, evaluation of biological activity of spheroids without dissolution is quite important. In this study, we focus on a force sensor for mechanical characterization of spheroids. The force sensor probe which has wide measurement range is highly required for evaluating stiffness of spheroid in medium environment because spheroid has nonlinear mechanical characteristics. Herein, we present a force sensor probe using quartz crystal resonator (QCR). The proposed force sensor probe has wide measurement range of 104 and waterproof structure. We evaluated its performance and mechanical characterization of HepG2 spheroids by using the proposed force sensor probe.
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M3 - Conference contribution
AN - SCOPUS:85014154099
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 1382
EP - 1383
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -