TY - JOUR
T1 - Formation and characterization of caseinate-chitosan nanocomplexes for encapsulation of Curcumin
AU - Razi, Muhamad Alif
AU - Wakabayashi, Rie
AU - Goto, Masahiro
AU - Kamiya, Noriho
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number JP16H06369 from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. MEXT scholarship provided to M.A.R (scholarship ID No. 150043) is gratefully acknowledged.
Publisher Copyright:
© 2018 The Society of Chemical Engineers, Japan.
PY - 2018
Y1 - 2018
N2 - Curcumin holds promise as a therapeutic agent due to its capability of conferring several pharmacological activities. While curcumin shows efficacy in preclinical studies as an anti-cancer agent, its translation into the clinic as a drug has yet to be realized. One possible reason is its poor solubility and stability in water, which decreases the bioavailability. Here, we report the formation of biocompatible nanocomplexes (NCs) from caseinate (CS) and chitosan (CH) using an electrostatic interaction-based approach to stabilize and enhance water solubility of curcumin. The formation of CS-CH NCs (CCNCs) was studied as a function of CH concentration. We show that positively charged NCs, having size between approx. 250 nm with a narrow distribution was formed by adjusting CH concentration. CCNCs successfully entrapped curcumin with a high entrapment efficiency. Curcumin was possibly located in a hydrophobic region of CS as indicated by a blue-shift in the emission maxima of curcumin. Ultimately, the stability and water solubility of curcumin in CCNCs could be remarkably enhanced. These results suggest that CCNCs would be useful for increasing the potential of curcumin as a preventive or therapeutic agent.
AB - Curcumin holds promise as a therapeutic agent due to its capability of conferring several pharmacological activities. While curcumin shows efficacy in preclinical studies as an anti-cancer agent, its translation into the clinic as a drug has yet to be realized. One possible reason is its poor solubility and stability in water, which decreases the bioavailability. Here, we report the formation of biocompatible nanocomplexes (NCs) from caseinate (CS) and chitosan (CH) using an electrostatic interaction-based approach to stabilize and enhance water solubility of curcumin. The formation of CS-CH NCs (CCNCs) was studied as a function of CH concentration. We show that positively charged NCs, having size between approx. 250 nm with a narrow distribution was formed by adjusting CH concentration. CCNCs successfully entrapped curcumin with a high entrapment efficiency. Curcumin was possibly located in a hydrophobic region of CS as indicated by a blue-shift in the emission maxima of curcumin. Ultimately, the stability and water solubility of curcumin in CCNCs could be remarkably enhanced. These results suggest that CCNCs would be useful for increasing the potential of curcumin as a preventive or therapeutic agent.
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U2 - 10.1252/jcej.17we293
DO - 10.1252/jcej.17we293
M3 - Article
AN - SCOPUS:85047764988
SN - 0021-9592
VL - 51
SP - 445
EP - 453
JO - Journal of Chemical Engineering of Japan
JF - Journal of Chemical Engineering of Japan
IS - 5
ER -
