Formation of ginsenoside-protein conjugates

Hoon Park; Yukihiro Shoyama; Li jiang Xuan; Hiroyuki Tanaka

doi:10.1016/S0928-3420(99)80011-1

Formation of ginsenoside-protein conjugates

Hoon Park, Yukihiro Shoyama, Li jiang Xuan, Hiroyuki Tanaka

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article

Abstract

Abstract-Ginsenoside Rbl was conjugated with bovine serum albumin by NaIO4. MALDI/MS spectrum of the conjugates revealed that most abundant conjugate had 10.2 moles of hapten(ginsenoside) and hapten number ranged from 0.6 moles to 24.6 moles. Ginsenoside-protein conjugate formation was also proved using ginsenoside Rc-HSA conjugate by PAGE gelelectrophoresis. With mercaptoethanol hapten number of conjugate seemed increased but solubility decreased. Monoclonal antibody formation is under investigation with ginsenoside-BSA conjugate.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Studies in Plant Science
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/S0928-3420(99)80011-1
Publication status	Published - Dec 1 1999

All Science Journal Classification (ASJC) codes

Plant Science

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Park, H., Shoyama, Y., Xuan, L. J., & Tanaka, H. (1999). Formation of ginsenoside-protein conjugates. Studies in Plant Science, 6(C), 83-86. https://doi.org/10.1016/S0928-3420(99)80011-1

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abstract = "Abstract-Ginsenoside Rbl was conjugated with bovine serum albumin by NaIO4. MALDI/MS spectrum of the conjugates revealed that most abundant conjugate had 10.2 moles of hapten(ginsenoside) and hapten number ranged from 0.6 moles to 24.6 moles. Ginsenoside-protein conjugate formation was also proved using ginsenoside Rc-HSA conjugate by PAGE gelelectrophoresis. With mercaptoethanol hapten number of conjugate seemed increased but solubility decreased. Monoclonal antibody formation is under investigation with ginsenoside-BSA conjugate.",

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AU - Park, Hoon

AU - Shoyama, Yukihiro

AU - Xuan, Li jiang

AU - Tanaka, Hiroyuki

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Abstract-Ginsenoside Rbl was conjugated with bovine serum albumin by NaIO4. MALDI/MS spectrum of the conjugates revealed that most abundant conjugate had 10.2 moles of hapten(ginsenoside) and hapten number ranged from 0.6 moles to 24.6 moles. Ginsenoside-protein conjugate formation was also proved using ginsenoside Rc-HSA conjugate by PAGE gelelectrophoresis. With mercaptoethanol hapten number of conjugate seemed increased but solubility decreased. Monoclonal antibody formation is under investigation with ginsenoside-BSA conjugate.

AB - Abstract-Ginsenoside Rbl was conjugated with bovine serum albumin by NaIO4. MALDI/MS spectrum of the conjugates revealed that most abundant conjugate had 10.2 moles of hapten(ginsenoside) and hapten number ranged from 0.6 moles to 24.6 moles. Ginsenoside-protein conjugate formation was also proved using ginsenoside Rc-HSA conjugate by PAGE gelelectrophoresis. With mercaptoethanol hapten number of conjugate seemed increased but solubility decreased. Monoclonal antibody formation is under investigation with ginsenoside-BSA conjugate.

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