Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Hamdy K. Assaf, Alaa M. Nafady, Ahmed E. Allam, Ashraf N.E. Hamed, Mohamed S. Kamel, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

Abstract

Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

Original languageEnglish
Pages (from-to)2452-2456
Number of pages5
JournalNatural Product Research
Volume32
Issue number20
DOIs
Publication statusPublished - Oct 18 2018

Fingerprint

ceramides
Ceramides
Inhibitory Concentration 50
aerial parts
inhibitory concentration 50
Urticaceae
Cells
Antennas
chemical constituents of plants
fluorouracil
Cell Line
human cell lines
Traditional Medicine
traditional medicine
Bioactivity
colorectal neoplasms
Human Activities
Fluorouracil
chemical structure
Medicine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn. / Assaf, Hamdy K.; Nafady, Alaa M.; Allam, Ahmed E.; Hamed, Ashraf N.E.; Kamel, Mohamed S.; Shimizu, Kuniyoshi.

In: Natural Product Research, Vol. 32, No. 20, 18.10.2018, p. 2452-2456.

Research output: Contribution to journalArticle

Assaf, Hamdy K. ; Nafady, Alaa M. ; Allam, Ahmed E. ; Hamed, Ashraf N.E. ; Kamel, Mohamed S. ; Shimizu, Kuniyoshi. / Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn. In: Natural Product Research. 2018 ; Vol. 32, No. 20. pp. 2452-2456.
@article{cda0911457a648a293b3fcd120145ce4,
title = "Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.",
abstract = "Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).",
author = "Assaf, {Hamdy K.} and Nafady, {Alaa M.} and Allam, {Ahmed E.} and Hamed, {Ashraf N.E.} and Kamel, {Mohamed S.} and Kuniyoshi Shimizu",
year = "2018",
month = "10",
day = "18",
doi = "10.1080/14786419.2017.1419234",
language = "English",
volume = "32",
pages = "2452--2456",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "20",

}

TY - JOUR

T1 - Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

AU - Assaf, Hamdy K.

AU - Nafady, Alaa M.

AU - Allam, Ahmed E.

AU - Hamed, Ashraf N.E.

AU - Kamel, Mohamed S.

AU - Shimizu, Kuniyoshi

PY - 2018/10/18

Y1 - 2018/10/18

N2 - Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

AB - Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

UR - http://www.scopus.com/inward/record.url?scp=85039162076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039162076&partnerID=8YFLogxK

U2 - 10.1080/14786419.2017.1419234

DO - 10.1080/14786419.2017.1419234

M3 - Article

C2 - 29281899

AN - SCOPUS:85039162076

VL - 32

SP - 2452

EP - 2456

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 20

ER -