Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Hamdy K. Assaf, Alaa M. Nafady, Ahmed E. Allam, Ashraf N.E. Hamed, Mohamed S. Kamel, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (1H, 13C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC50 33.25 μM in comparison with 5-fluorouracil IC50 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).

Original languageEnglish
Pages (from-to)2452-2456
Number of pages5
JournalNatural Product Research
Volume32
Issue number20
DOIs
Publication statusPublished - Oct 18 2018

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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