Fosfomycin inhibits NF-κB activation in U-937 and Jurkat cells

Yasuto Yoneshima, Takashi Ichiyama, Hiroshi Ayukawa, Tomoyo Matsubara, Susumu Furukawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fosfomycin exerts anti-inflammatory effects through inhibiting the production of proinflammatory cytokines. Transcription of the genes for these proinflammatory cytokines is regulated by NF-κB. We tested the hypothesis that fosfomycin inhibits the activation of NF-κB induced by tumor necrosis factor-α (TNF-α) in human monocytic U-937 cells, and a T cell line (Jurkat). Western blot analysis demonstrated that fosfomycin inhibits NF-κB activation in both cells. Flow cytometry revealed that fosfomycin suppresses NF-κB activation in both cells in a dose-related manner. These findings are consistent with the idea that fosfomycin suppresses the production of proinflammatory cytokines via inhibition of NF-κB activation.

Original languageEnglish
Pages (from-to)589-592
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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