Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Nobuyuki Ono; Kyoko Yoshihiro; Daisuke Oryoji; Motohiro Matsuda; Yoshihiro Ueki; Shigehiro Uezono; Yasufumi Kai; Daisuke Himeji; Hiroaki Niiro; Akira Ueda

doi:10.1007/s10165-012-0682-1

Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Nobuyuki Ono, Kyoko Yoshihiro, Daisuke Oryoji, Motohiro Matsuda, Yoshihiro Ueki, Shigehiro Uezono, Yasufumi Kai, Daisuke Himeji, Hiroaki Niiro, Akira Ueda

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7 Citations (Scopus)

Abstract

Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.

Original language	English
Pages (from-to)	554-563
Number of pages	10
Journal	Modern Rheumatology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/s10165-012-0682-1
Publication status	Published - May 2013

All Science Journal Classification (ASJC) codes

Rheumatology

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10.1007/s10165-012-0682-1

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title = "Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature",

abstract = "Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.",

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AU - Ono, Nobuyuki

AU - Yoshihiro, Kyoko

AU - Oryoji, Daisuke

AU - Matsuda, Motohiro

AU - Ueki, Yoshihiro

AU - Uezono, Shigehiro

AU - Kai, Yasufumi

AU - Himeji, Daisuke

AU - Niiro, Hiroaki

AU - Ueda, Akira

PY - 2013/5

Y1 - 2013/5

N2 - Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.

AB - Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.

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Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Abstract

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