Foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka

Toshiya Nishimura, Tetsuya Sato, Yasuhiro Yamamoto, Ikuko Watakabe, Yasuyuki Ohkawa, Mikita Suyama, Satoru Kobayashi, Minoru Tanaka

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalScience
Volume349
Issue number6245
DOIs
Publication statusPublished - Jul 17 2015

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All Science Journal Classification (ASJC) codes

  • General

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