Free radical imaging of endogenous redox molecules using dynamic nuclear polarization magnetic resonance imaging

Fuminori Hyodo, Shinji Ito, Hinako Eto, Abdelazim Elsayed Elhelaly, Masaharu Murata, Tomohiko Akahoshi, Hideo Utsumi, Masayuki Matuso

Research output: Contribution to journalReview articlepeer-review

Abstract

Redox reactions accompanied by the oxidation–reduction of endogenous molecules play important roles in maintaining homeostasis in living organisms. In humans, numerous endogenous molecules that contribute toward maintaining physiological conditions form free radicals via electron transfer. A typical example of this is the mitochondrial electron transport chain, which is involved in energy production. If free radicals derived from endogenous molecules could be visualized and exploited as biological and functional probes, redox reactions mediated by endogenous molecules could be detected non-invasively. We succeeded in visualizing the free radicals derived from endogenous molecules using an in vivo dynamic nuclear polarization (DNP) magnetic resonance imaging (MRI) system. In this review, we describe the visualization of endogenous redox molecules, such as flavins and ubiquinones, which are mitochondrial electron carriers, as well as vitamin E and vitamin C (ascorbate). In addition, we describe the application of melanin free radicals for the in vivo visualization of metabola without using probes via in vivo DNP-MRI.

Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalFree Radical Research
Volume55
Issue number4
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry

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