From organoids to transplantable artificial kidneys

Hidekazu Naganuma, Ryuichi Nishinakamura

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

It is difficult to restore kidney function following chronic kidney damage. Although dialysis is currently used to treat patients with chronic kidney disease, it does not cure the disease, while severely restricting the patient's daily and social activities. Kidney transplantation is an alternative and curative therapy, but donor numbers remain limited. However, the generation of kidney organoids from human induced pluripotent stem cells represents an important recent advance in regenerative medicine. Kidney organoids are expected to be used for disease modeling and drug discovery, and may eventually be applicable for transplantation. In this review, we describe the current status of kidney organoids and discuss the hurdles that need to be overcome to generate transplantable artificial kidneys.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalTransplant International
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 2019

All Science Journal Classification (ASJC) codes

  • Transplantation

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