From structure to mechanism— understanding initiation of DNA replication

Alberto Riera, Marta Barbon, Yasunori Noguchi, L. Maximilian Reuter, Sarah Schneider, Christian Speck

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

DNA replication results in the doubling of the genome prior to cell division. This process requires the assembly of 50 or more protein factors into a replication fork. Here, we review recent structural and biochemical insights that start to explain how specific proteins recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands, and reassemble chromatin. We focus on the minichromosome maintenance (MCM2–7) proteins, which form the core of the eukaryotic replication fork, as this complex undergoes major structural rearrangements in order to engage with DNA, regulate its DNA-unwinding activity, and maintain genome stability.

Original languageEnglish
Pages (from-to)1073-1088
Number of pages16
JournalGenes and Development
Volume31
Issue number11
DOIs
Publication statusPublished - 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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