Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome

Hikaru Doi, Kimiyoshi Arimura, Yasumasa Ohyagi, Jun-Ichi Kira

Research output: Contribution to journalArticle

Abstract

A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.

Original languageEnglish
Pages (from-to)1113-1115
Number of pages3
JournalInternal Medicine
Volume50
Issue number10
DOIs
Publication statusPublished - Jun 1 2011

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Isaacs Syndrome
Frostbite
Muscle Rigidity
Voltage-Gated Potassium Channels
Skin
Hypesthesia
Myalgia
Foot
Extremities
Pain
Antibodies

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome. / Doi, Hikaru; Arimura, Kimiyoshi; Ohyagi, Yasumasa; Kira, Jun-Ichi.

In: Internal Medicine, Vol. 50, No. 10, 01.06.2011, p. 1113-1115.

Research output: Contribution to journalArticle

Doi, Hikaru ; Arimura, Kimiyoshi ; Ohyagi, Yasumasa ; Kira, Jun-Ichi. / Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome. In: Internal Medicine. 2011 ; Vol. 50, No. 10. pp. 1113-1115.
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