Frostbite-like skin lesion as an autonomic symptom of Isaacs' syndrome

Hikaru Doi, Kimiyoshi Arimura, Yasumasa Ohyagi, Jun ichi Kira

Research output: Contribution to journalArticlepeer-review


A 25-year-old woman complained of numbness of the extremities, following muscle rigidity and tenderness. The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. Twenty-seven months after the first symptom, she developed a pricking pain sensation in the lateral left foot, and then gradually developed a purple skin lesion resembling frostbite. The lesion completely disappeared 2 days later. An incidental episode occurred at the same site 8 months later. Frostbite-like skin lesions may be a rare autonomic manifestation in Isaacs' syndrome.

Original languageEnglish
Pages (from-to)1113-1115
Number of pages3
JournalInternal Medicine
Issue number10
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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