Full thickness macular hole case after intravitreal aflibercept treatment

Yuji Oshima, Rajendra S. Apte, Shintaro Nakao, Shigeo Yoshida, Tatsuro Ishibashi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The pathogenesis of macular hole formation is widely accepted as a tractional force at the vitreo-retinal interface in fovea. We report a case of macular hole after intravitreous aflibercept injection for age-related macular degeneration (AMD) associated with contraction of the retinal pigment epithelium (RPE) at the edge of a fibrovascular pigment epithelial detachment (PED). Case presentation: A 94-year old man with neovascular AMD affecting his left eye accompanied by a fibrovascular PED was examined for severe vision loss. Although RPE tear in his left eye was identified before the first aflibercept intravitreous injection performed in order to treat neovascular AMD, he received three aflibercept injections as induction treatment. After induction treatment, a full thickness macular hole was identified associated with the contracted rolled RPE edge beneath the retina. Conclusion: Macular hole is commonly formed associated with tangential vitreous traction. Current report suggests that rapid contraction of the RPE underneath the retina can be one of the causes of a macular hole, and one of the side effects of anti-VEGF therapy for neovascular AMD.

Original languageEnglish
Article number30
JournalBMC Ophthalmology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Retinal Perforations
Retinal Pigment Epithelium
Macular Degeneration
Injections
Retina
Therapeutics
Traction
Vascular Endothelial Growth Factor A
aflibercept

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Full thickness macular hole case after intravitreal aflibercept treatment. / Oshima, Yuji; Apte, Rajendra S.; Nakao, Shintaro; Yoshida, Shigeo; Ishibashi, Tatsuro.

In: BMC Ophthalmology, Vol. 15, No. 1, 30, 01.01.2015.

Research output: Contribution to journalArticle

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