Functional and structural deficits in brain regions subserving face perception in schizophrenia

Toshiaki Onitsuka, Margaret A. Niznikiewicz, Kevin M. Spencer, Melissa Frumin, Noriomi Kuroki, Lisa C. Lucia, Martha E. Shenton, Robert W. McCarley

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Objective: Schizophrenia impairs many cognitive functions, including face perception. Veridical face perception is critical for social interaction, including distinguishing friend from foe and familiar from unfamiliar faces. The main aim of this study was to determine whether patients with schizophrenia show less activation in neural networks related to face processing, compared with healthy subjects, and to investigate the relationships between this functional abnormality and anatomical abnormalities in the fusiform gyrus shown with magnetic resonance imaging (MRI). Method: Twenty male chronic schizophrenia patients and 16 healthy comparison subjects matched with the patients for age, gender, handedness, and parental socioeconomic status underwent high-spatial-resolution MRI. Event-related potentials elicited by images of faces, cars, and hands were recorded in a separate session. Results: Compared to the healthy subjects, the patients with schizophrenia showed bilateral N170 amplitude reduction in response to images of faces but not to images of other objects. The patients also had smaller bilateral anterior and posterior fusiform gyrus gray matter volumes, compared to the healthy subjects. In addition, right posterior fusiform gyrus volume was significantly correlated with N170 amplitude measured at the right posterior temporal electrode site in response to images of faces in the schizophrenia patients but not in the healthy comparison subjects. Conclusions: The results provide evidence for deficits in the early stages of face perception in schizophrenia. The association of these deficits with smaller fusiform gyrus volume in patients with schizophrenia, relative to healthy subjects, suggests that the fusiform gyrus is the site of a defective anatomical substrate for face processing in schizophrenia.

Original languageEnglish
Pages (from-to)455-462
Number of pages8
JournalAmerican Journal of Psychiatry
Volume163
Issue number3
DOIs
Publication statusPublished - Mar 1 2006

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Schizophrenia
Temporal Lobe
Healthy Volunteers
Brain
Magnetic Resonance Imaging
Functional Laterality
Facial Recognition
Interpersonal Relations
Evoked Potentials
Social Class
Cognition
Electrodes
Hand

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Onitsuka, T., Niznikiewicz, M. A., Spencer, K. M., Frumin, M., Kuroki, N., Lucia, L. C., ... McCarley, R. W. (2006). Functional and structural deficits in brain regions subserving face perception in schizophrenia. American Journal of Psychiatry, 163(3), 455-462. https://doi.org/10.1176/appi.ajp.163.3.455

Functional and structural deficits in brain regions subserving face perception in schizophrenia. / Onitsuka, Toshiaki; Niznikiewicz, Margaret A.; Spencer, Kevin M.; Frumin, Melissa; Kuroki, Noriomi; Lucia, Lisa C.; Shenton, Martha E.; McCarley, Robert W.

In: American Journal of Psychiatry, Vol. 163, No. 3, 01.03.2006, p. 455-462.

Research output: Contribution to journalArticle

Onitsuka, T, Niznikiewicz, MA, Spencer, KM, Frumin, M, Kuroki, N, Lucia, LC, Shenton, ME & McCarley, RW 2006, 'Functional and structural deficits in brain regions subserving face perception in schizophrenia', American Journal of Psychiatry, vol. 163, no. 3, pp. 455-462. https://doi.org/10.1176/appi.ajp.163.3.455
Onitsuka, Toshiaki ; Niznikiewicz, Margaret A. ; Spencer, Kevin M. ; Frumin, Melissa ; Kuroki, Noriomi ; Lucia, Lisa C. ; Shenton, Martha E. ; McCarley, Robert W. / Functional and structural deficits in brain regions subserving face perception in schizophrenia. In: American Journal of Psychiatry. 2006 ; Vol. 163, No. 3. pp. 455-462.
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