Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR

Yukiko Ogino, Saki Tohyama, Satomi Kohno, Kenji Toyota, Gen Yamada, Ryohei Yatsu, Tohru Kobayashi, Norihisa Tatarazako, Tomomi Sato, Hajime Matsubara, Anke Lange, Charles R. Tyler, Yoshinao Katsu, Taisen Iguchi, Shinichi Miyagawa

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Sex steroid hormones including estrogens and androgens play fundamental roles in regulating reproductive activities and they act through estrogen and androgen receptors (ESR and AR). These steroid receptors have evolved from a common ancestor in association with several gene duplications. In most vertebrates, this has resulted in two ESR subtypes (ESR1 and ESR2) and one AR, whereas in teleost fish there are at least three ESRs (ESR1, ESR2a and ESR2b) and two ARs (ARα and ARβ) due to a lineage-specific whole genome duplication. Functional distinctions have been suggested among these receptors, but to date their roles have only been characterized in a limited number of species. Sexual differentiation and the development of reproductive organs are indispensable for all animal species and in vertebrates these events depend on the action of sex steroid hormones. Here we review the recent progress in understanding of the functions of the ESRs and ARs in the development and expression of sexually dimorphic characteristics associated with steroid hormone signaling in vertebrates, with representative fish, amphibians, reptiles, birds and mammals.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume184
DOIs
Publication statusPublished - Nov 1 2018

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Steroid Receptors
Androgen Receptors
Gonadal Steroid Hormones
Estrogen Receptors
Paramagnetic resonance
Vertebrates
Fish
Fishes
Genes
Steroid hormones
Sex Differentiation
Sexual Development
Gene Duplication
Mammals
Reptiles
Birds
Amphibians
Androgens
Estrogens
Animals

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR. / Ogino, Yukiko; Tohyama, Saki; Kohno, Satomi; Toyota, Kenji; Yamada, Gen; Yatsu, Ryohei; Kobayashi, Tohru; Tatarazako, Norihisa; Sato, Tomomi; Matsubara, Hajime; Lange, Anke; Tyler, Charles R.; Katsu, Yoshinao; Iguchi, Taisen; Miyagawa, Shinichi.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 184, 01.11.2018, p. 38-46.

Research output: Contribution to journalReview article

Ogino, Y, Tohyama, S, Kohno, S, Toyota, K, Yamada, G, Yatsu, R, Kobayashi, T, Tatarazako, N, Sato, T, Matsubara, H, Lange, A, Tyler, CR, Katsu, Y, Iguchi, T & Miyagawa, S 2018, 'Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR', Journal of Steroid Biochemistry and Molecular Biology, vol. 184, pp. 38-46. https://doi.org/10.1016/j.jsbmb.2018.06.002
Ogino, Yukiko ; Tohyama, Saki ; Kohno, Satomi ; Toyota, Kenji ; Yamada, Gen ; Yatsu, Ryohei ; Kobayashi, Tohru ; Tatarazako, Norihisa ; Sato, Tomomi ; Matsubara, Hajime ; Lange, Anke ; Tyler, Charles R. ; Katsu, Yoshinao ; Iguchi, Taisen ; Miyagawa, Shinichi. / Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR. In: Journal of Steroid Biochemistry and Molecular Biology. 2018 ; Vol. 184. pp. 38-46.
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