Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis

H. Torisu, K. Kusuhara, R. Kira, W. M. Bassuny, Y. Sakai, M. Sanefuji, M. Takemoto, T. Hara

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: The antivirally active MxA protein is induced by interferon (IFN) α/β and inhibits the replication of single-stranded RNA viruses including measles virus (MV). The authors investigated whether the MxA gene contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individuals. Methods: Single-nucleotide polymorphisms (SNP) in the promoter region of the MxA gene were screened, association studies were performed between two SNP and SSPE, and then a functional difference in the promoter activities of the two SNP was investigated by a dual luciferase reporter assay. Results: Four SNP were found (-88 G/T, -123 C/A, -200 T/C, and -213 G/T), and SSPE patients exhibited a higher frequency of both the -88T allele and the -88TT genotype than controls (p = 0.040 and 0.003). The IFN-induced up-regulation of the MxA promoter activity of the sequence with -88T was found to be significantly higher than that with G. Conclusions: MxA promoter -88 G/T SNP may confer host genetic susceptibility to SSPE in Japanese individuals. The finding that homozygotes of the MxA -88T allele with a high MxA-producing capability were more frequently seen in SSPE patients suggests that the MxA protein promotes the establishment of persistent MV infection of neural cells.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalNeurology
Volume62
Issue number3
DOIs
Publication statusPublished - Feb 10 2004

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Subacute Sclerosing Panencephalitis
Single Nucleotide Polymorphism
Measles virus
Interferons
Alleles
RNA Viruses
Homozygote
Virus Diseases
Genetic Predisposition to Disease
Luciferases
Genetic Promoter Regions
Genes
Proteins
Up-Regulation
Genotype

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Torisu, H., Kusuhara, K., Kira, R., Bassuny, W. M., Sakai, Y., Sanefuji, M., ... Hara, T. (2004). Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. Neurology, 62(3), 457-460. https://doi.org/10.1212/01.WNL.0000106940.95749.8E

Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. / Torisu, H.; Kusuhara, K.; Kira, R.; Bassuny, W. M.; Sakai, Y.; Sanefuji, M.; Takemoto, M.; Hara, T.

In: Neurology, Vol. 62, No. 3, 10.02.2004, p. 457-460.

Research output: Contribution to journalArticle

Torisu, H, Kusuhara, K, Kira, R, Bassuny, WM, Sakai, Y, Sanefuji, M, Takemoto, M & Hara, T 2004, 'Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis', Neurology, vol. 62, no. 3, pp. 457-460. https://doi.org/10.1212/01.WNL.0000106940.95749.8E
Torisu, H. ; Kusuhara, K. ; Kira, R. ; Bassuny, W. M. ; Sakai, Y. ; Sanefuji, M. ; Takemoto, M. ; Hara, T. / Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. In: Neurology. 2004 ; Vol. 62, No. 3. pp. 457-460.
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