Functional platform for controlled subcellular distribution of carbon nanotubes

Maged F. Serag, Noritada Kaji, Enrica Venturelli, Yukihiro Okamoto, Kazuyoshi Terasaka, Manabu Tokeshi, Hajime Mizukami, Kevin Braeckmans, Alberto Bianco, Yoshinobu Baba

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.

Original languageEnglish
Pages (from-to)9264-9270
Number of pages7
JournalACS nano
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 22 2011
Externally publishedYes

Fingerprint

Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Carbon nanotubes
Carrier transport
platforms
carbon nanotubes
Cytology
toxicity
Toxicity
elimination
Tissue
Nanoparticles
membranes
Membranes
nanoparticles
cells

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Serag, M. F., Kaji, N., Venturelli, E., Okamoto, Y., Terasaka, K., Tokeshi, M., ... Baba, Y. (2011). Functional platform for controlled subcellular distribution of carbon nanotubes. ACS nano, 5(11), 9264-9270. https://doi.org/10.1021/nn2035654

Functional platform for controlled subcellular distribution of carbon nanotubes. / Serag, Maged F.; Kaji, Noritada; Venturelli, Enrica; Okamoto, Yukihiro; Terasaka, Kazuyoshi; Tokeshi, Manabu; Mizukami, Hajime; Braeckmans, Kevin; Bianco, Alberto; Baba, Yoshinobu.

In: ACS nano, Vol. 5, No. 11, 22.11.2011, p. 9264-9270.

Research output: Contribution to journalArticle

Serag, MF, Kaji, N, Venturelli, E, Okamoto, Y, Terasaka, K, Tokeshi, M, Mizukami, H, Braeckmans, K, Bianco, A & Baba, Y 2011, 'Functional platform for controlled subcellular distribution of carbon nanotubes', ACS nano, vol. 5, no. 11, pp. 9264-9270. https://doi.org/10.1021/nn2035654
Serag MF, Kaji N, Venturelli E, Okamoto Y, Terasaka K, Tokeshi M et al. Functional platform for controlled subcellular distribution of carbon nanotubes. ACS nano. 2011 Nov 22;5(11):9264-9270. https://doi.org/10.1021/nn2035654
Serag, Maged F. ; Kaji, Noritada ; Venturelli, Enrica ; Okamoto, Yukihiro ; Terasaka, Kazuyoshi ; Tokeshi, Manabu ; Mizukami, Hajime ; Braeckmans, Kevin ; Bianco, Alberto ; Baba, Yoshinobu. / Functional platform for controlled subcellular distribution of carbon nanotubes. In: ACS nano. 2011 ; Vol. 5, No. 11. pp. 9264-9270.
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