Functional regulation of biomolecule using DNA-conjugation.

Takahisa Anada, Takeshi Kano, Wataru Kaku, Yoshiki Katayama, Mizuo Maeda, Masaharu Murata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

3'-methacryloyl-oligodeoxynucleotide having antisense sequence against messenger RNA of green fluorescent protein and N-isopropylacrylamide were co-polymerized. The conjugate can reversibly change its conformation at around a transition temperature, similarly to N-isopropylacrylamide homopolymer. We achieved artificially regulation of gene expression depending on temperature using the conjugate.

Original languageEnglish
Pages (from-to)269-270
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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