Functional regulation of DNA nanomachine by artificial nucleic acid chaperon

Sung Won Choi; Naoki Makita; Arihiro Kano; Asako Yamayoshi; Toshihiro Akaike; Atsushi Maruyama

Functional regulation of DNA nanomachine by artificial nucleic acid chaperon

Sung Won Choi, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

Department of Fundamental Organic Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For better applications and developments of DNA nanomachines, their responding outputs and sequence-selectivity need to be improved. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces robust and quick responses of DNA-fueled nanomachines under moderate conditions including physiologically relevant conditions through hybrid stabilization and DNA strand exchange acceleration.

Original language	English
Title of host publication	55th SPSJ Symposium on Macromolecules
Pages	5272-5273
Number of pages	2
Volume	55
Edition	2
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sep 20 2006 → Sep 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	Japan
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "Functional regulation of DNA nanomachine by artificial nucleic acid chaperon",

abstract = "The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For better applications and developments of DNA nanomachines, their responding outputs and sequence-selectivity need to be improved. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces robust and quick responses of DNA-fueled nanomachines under moderate conditions including physiologically relevant conditions through hybrid stabilization and DNA strand exchange acceleration.",

author = "Choi, {Sung Won} and Naoki Makita and Arihiro Kano and Asako Yamayoshi and Toshihiro Akaike and Atsushi Maruyama",

year = "2006",

language = "English",

volume = "55",

pages = "5272--5273",

booktitle = "55th SPSJ Symposium on Macromolecules",

edition = "2",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - GEN

T1 - Functional regulation of DNA nanomachine by artificial nucleic acid chaperon

AU - Choi, Sung Won

AU - Makita, Naoki

AU - Kano, Arihiro

AU - Yamayoshi, Asako

AU - Akaike, Toshihiro

AU - Maruyama, Atsushi

PY - 2006

Y1 - 2006

N2 - The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For better applications and developments of DNA nanomachines, their responding outputs and sequence-selectivity need to be improved. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces robust and quick responses of DNA-fueled nanomachines under moderate conditions including physiologically relevant conditions through hybrid stabilization and DNA strand exchange acceleration.

AB - The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For better applications and developments of DNA nanomachines, their responding outputs and sequence-selectivity need to be improved. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces robust and quick responses of DNA-fueled nanomachines under moderate conditions including physiologically relevant conditions through hybrid stabilization and DNA strand exchange acceleration.

UR - http://www.scopus.com/inward/record.url?scp=33846130085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846130085&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33846130085

VL - 55

SP - 5272

EP - 5273

BT - 55th SPSJ Symposium on Macromolecules

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -