Functional regulation of DNA nanomachine by artificial nucleic acid chaperon

Sung Won Choi, Naoki Makita, Arihiro Kano, Asako Yamayoshi, Toshihiro Akaike, Atsushi Maruyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The unique folding and assembling properties of DNA have been elaborated to construct various nanomachines that can be reversibly switched between two or more distinct conformations. For better applications and developments of DNA nanomachines, their responding outputs and sequence-selectivity need to be improved. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces robust and quick responses of DNA-fueled nanomachines under moderate conditions including physiologically relevant conditions through hybrid stabilization and DNA strand exchange acceleration.

Original languageEnglish
Title of host publication55th SPSJ Symposium on Macromolecules
Pages5272-5273
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

Fingerprint

Nucleic acids
DNA
Dextran
Grafts
Conformations
Copolymers
Stabilization

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Choi, S. W., Makita, N., Kano, A., Yamayoshi, A., Akaike, T., & Maruyama, A. (2006). Functional regulation of DNA nanomachine by artificial nucleic acid chaperon. In 55th SPSJ Symposium on Macromolecules (2 ed., Vol. 55, pp. 5272-5273)

Functional regulation of DNA nanomachine by artificial nucleic acid chaperon. / Choi, Sung Won; Makita, Naoki; Kano, Arihiro; Yamayoshi, Asako; Akaike, Toshihiro; Maruyama, Atsushi.

55th SPSJ Symposium on Macromolecules. Vol. 55 2. ed. 2006. p. 5272-5273.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Choi, SW, Makita, N, Kano, A, Yamayoshi, A, Akaike, T & Maruyama, A 2006, Functional regulation of DNA nanomachine by artificial nucleic acid chaperon. in 55th SPSJ Symposium on Macromolecules. 2 edn, vol. 55, pp. 5272-5273, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 9/20/06.
Choi SW, Makita N, Kano A, Yamayoshi A, Akaike T, Maruyama A. Functional regulation of DNA nanomachine by artificial nucleic acid chaperon. In 55th SPSJ Symposium on Macromolecules. 2 ed. Vol. 55. 2006. p. 5272-5273
Choi, Sung Won ; Makita, Naoki ; Kano, Arihiro ; Yamayoshi, Asako ; Akaike, Toshihiro ; Maruyama, Atsushi. / Functional regulation of DNA nanomachine by artificial nucleic acid chaperon. 55th SPSJ Symposium on Macromolecules. Vol. 55 2. ed. 2006. pp. 5272-5273
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