Functional segregation and development of mouse higher visual areas

Tomonari Murakami, Teppei Matsui, Kenichi Ohki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Recent studies suggest that higher visual areas (HVAs) in the mouse visual cortex are segregated anatomically into two visual streams, likely analogous to the ventral and dorsal streams in primates. However, HVAs in mice have yet to be characterized functionally. Moreover, it is unknown when the functional segregation of HVAs occurs during development. Here, we investigated spatiotemporal selectivity of HVAs and their development using wide-field calcium imaging. We found that lateral HVAs in the anatomical ventral stream shared similar spatiotemporal selectivity, whereas the spatiotemporal selectivity of anterior and medial HVAs in the anatomical dorsal stream was not uniform and these areas were segregated functionally into multiple groups. This functional segregation of HVAs developed and reached an adult-like pattern ~ 10 d after eye opening (EO). These results suggest, not only the functional segregation of ventral and dorsal streams, but also the presence of multiple substreams in the dorsal stream, and indicate that the functional segregation of visual streams occurs gradually after EO.

Original languageEnglish
Pages (from-to)9424-9437
Number of pages14
JournalJournal of Neuroscience
Volume37
Issue number39
DOIs
Publication statusPublished - Sep 27 2017

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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