Functional similarities and uniqueness of p27 and p57: Insight from a knock-in mouse model

Etsuo Susaki, Keiichi I. Nakayama

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

The cyclin-dependent kinase inhibitors (CKIs) p27 and p57 are structurally similar, and their biochemical and cellular functions have been thought to be equivalent. However, mice deficient in either p27 or p57 exhibit markedly different phenotypes, suggesting that the in vivo roles of these two proteins might differ. To address this apparent discrepancy, we have generated a knock-in mouse model in which the endogenous p57 gene is replaced by the p27 gene, with p27 thus being expressed instead of p57. This mouse model has provided evidence that p57 functions as a bona fide CKI in vivo and that most of its roles can be performed by p27. Our findings also highlight and provide insight into the question of what determines the distinct cellular responses to abnormal cell cycling induced by the loss of CKIs.

Original languageEnglish
Pages (from-to)2497-2501
Number of pages5
JournalCell Cycle
Volume8
Issue number16
DOIs
Publication statusPublished - Aug 15 2009

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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