Functional T cell receptor δ chain gene messages in athymic nude mice

Yasunobu Yoshikai, Goro Matsuzaki, Yasuyuki Takeda, Shouichi Ohga, Kenji Kishihara, Hiroyuki Yuuki, Kikuo Nomoto

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The rearrangement and expression of T cell antigen receptor (TcR) δ chain genes were investigated in congenitally athymic nude mice. The lymphoid cells derived from nude mice showed evidence of rearranged δ chain genes and a relatively high level of δ chain gene messages. Nucleotide sequence analysis revealed that nude mice contained an in‐frame δ chain transcript, composed of Vδ5‐Dδ1‐Dδ2‐Jδ1‐Cδ genes in the spleen. We have previously described functionally rearranged TcR γchain genes in the spleen of nude mice. Taken together, T cell precursors appear to proliferate and differentiate along the extrathymic pathway into TcR γ/δ‐bearing T cells in nude mice.

    Original languageEnglish
    Pages (from-to)1039-1043
    Number of pages5
    JournalEuropean Journal of Immunology
    Volume18
    Issue number7
    DOIs
    Publication statusPublished - Jul 1988

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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  • Cite this

    Yoshikai, Y., Matsuzaki, G., Takeda, Y., Ohga, S., Kishihara, K., Yuuki, H., & Nomoto, K. (1988). Functional T cell receptor δ chain gene messages in athymic nude mice. European Journal of Immunology, 18(7), 1039-1043. https://doi.org/10.1002/eji.1830180711