Functions of angiotensin peptides in the rostral ventrolateral medulla

R. A.L. Dampney, Y. Hirooka, P. D. Potts, G. A. Head

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

1. It was first shown several years ago that the rostral part of the ventrolateral medulla (VLM) contains a high density of receptor binding sites for angiotensin II (AngII). In the present paper we briefly review recent studies aimed at determining the actions of both exogenous and endogenous angiotensin peptides in the rostral VLM, as well as their specific sites of action. 2. The results of these studies have shown that angiotensin peptides can excite pressor and sympathoexcitatory neurons in the rostral VLM, but do not appear to affect non-cardiovascular neurons in this region. 3. If is known that pressor neurons in the rostral VLM include both catecholamine and non-catecholamine neurons. There is evidence that, at least in conscious rabbits, both of these types of neurons are activated by AngII. The specific endogenous angiotensin peptide or peptides that affect pressor neurons in the rostral VLM have not yet been definitively identified. 4. It is also possible that different angiotensin peptides may have different effects on pressor neurons in the rostral VLM, mediated by different receptors. Further studies will be needed to define these different functions as well as the specific receptors and cellular mechanisms that subserve them.

Original languageEnglish
Pages (from-to)S105-S111
JournalClinical and Experimental Pharmacology and Physiology
Volume23
Issue numberSUPPL. 3
Publication statusPublished - Dec 30 1996

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Angiotensins
Neurons
Peptides
Angiotensin II
Catecholamines
Binding Sites
Rabbits

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Dampney, R. A. L., Hirooka, Y., Potts, P. D., & Head, G. A. (1996). Functions of angiotensin peptides in the rostral ventrolateral medulla. Clinical and Experimental Pharmacology and Physiology, 23(SUPPL. 3), S105-S111.

Functions of angiotensin peptides in the rostral ventrolateral medulla. / Dampney, R. A.L.; Hirooka, Y.; Potts, P. D.; Head, G. A.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 23, No. SUPPL. 3, 30.12.1996, p. S105-S111.

Research output: Contribution to journalArticle

Dampney, RAL, Hirooka, Y, Potts, PD & Head, GA 1996, 'Functions of angiotensin peptides in the rostral ventrolateral medulla', Clinical and Experimental Pharmacology and Physiology, vol. 23, no. SUPPL. 3, pp. S105-S111.
Dampney RAL, Hirooka Y, Potts PD, Head GA. Functions of angiotensin peptides in the rostral ventrolateral medulla. Clinical and Experimental Pharmacology and Physiology. 1996 Dec 30;23(SUPPL. 3):S105-S111.
Dampney, R. A.L. ; Hirooka, Y. ; Potts, P. D. ; Head, G. A. / Functions of angiotensin peptides in the rostral ventrolateral medulla. In: Clinical and Experimental Pharmacology and Physiology. 1996 ; Vol. 23, No. SUPPL. 3. pp. S105-S111.
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