Functions of brain L-aspartate and its derivatives on stress responses

Shozo Tomonaga, Edi Erwan, D. Michael Denbow, Mitsuhiro Furuse

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

L-Aspartate (L-Asp) functions as a neurotransmitter to stimulate the N-methyl-D-aspartate (NMDA) receptor (NMDA-R), one of the ionotropic L-glutamate receptors, even though its binding capacity for NMDA-R is weaker than L-glutamate. The amino acid L-Asp, as well as its enantiomer D-aspartate (D-Asp), occurs in the central nervous system of various species including chickens, pigeons, rats, mice and humans. D-Asp, synthesized from L-Asp by aspartate racemase, can also directly stimulate the NMDA-R. Furthermore, D-Asp may indirectly stimulate NMDA-R because it is a substrate for endogenous NMDA. Central injection of L-Asp and L-asparagine derived from L-Asp via transamidation decreased social separation-induced stress responses. In addition, central injection of NMDA can attenuate the stress responses while some reports indicate that stimulation of the NMDA-R has negative impacts on stress responses. Central L-Asp may act on stress responses not only directly but also via its metabolites, and the effects may depend on the type of stressors and/or brain regions.

Original languageEnglish
Title of host publicationTyrosine and Aspartic Acid
Subtitle of host publicationProperties, Sources and Health Benefits
PublisherNova Science Publishers, Inc.
Pages163-175
Number of pages13
ISBN (Print)9781621007524
Publication statusPublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Tomonaga, S., Erwan, E., Denbow, D. M., & Furuse, M. (2012). Functions of brain L-aspartate and its derivatives on stress responses. In Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits (pp. 163-175). Nova Science Publishers, Inc..