Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan

Tsutomu Yasukawaid, Ryusaburo Mori, Miki Sawa, Ari Shinojima, Chikako Hara, Tetsuju Sekiryu, Yuji Oshima, Masaaki Saito, Yukinori Sugano, Aki Kato, Masayuki Ashikari, Yoshio Hirano, Hitomi Asato, Mayumi Nakamura, Kiyoshi Matsunoid, Noriyuki Kuno, Erika Kimura, Takeshi Nishiyama, Mitsuko Yuzawa, Tatsuro IshibashiYuichiro Ogura, Tomohiro Iida, Fumi Gomi

Research output: Contribution to journalArticle

Abstract

Purpose Abnormal fundus autofluorescence (FAF) potentially precedes onset of late age-related macular degeneration (AMD) in Caucasian patients. Many differences exist between Asian and Caucasian patients regarding AMD types and severity, gender, and genetic backgrounds. We investigated the characteristics of abnormal FAF and retinal sensitivity in the fellow eyes of Japanese patients with unilateral neovascular AMD. Methods Sixty-six patients with unilateral neovascular AMD and abnormal FAF in the fellow eye were enrolled in this multicenter, prospective, observational study. The best-corrected visual acuity, fundus photographs, FAF images, and retinal sensitivity on microperimetry were measured periodically for 12 months. The FAF images were classified into eight patterns based on the International Fundus Autofluorescence Classification Group. The points measured by microperimetry were superimposed onto the FAF images and fundus photographs and classified as "within," "close," and "distant," based on the distance from the abnormal FAF and other findings. The relationship between the location of the baseline abnormal FAF and retinal sensitivity was investigated. Results In Japanese patients, patchy (33.3%) and focally increased (30.3%) patterns predominated in the abnormal FAF. Intermediate-to-large drusen was associated predominantly with hyperfluorescence and hypofluorescence. Neovascular AMD developed within 1 year in six (9.1%) eyes, the mean baseline retinal sensitivity of which was 12.8 ± 4.7 dB, significantly (p<0.002) lower than the other eyes. In 44 of the other 60 eyes, microperimetry was measurable at baseline and month 12 and the mean retinal sensitivity improved significantly from 13.5 ± 4.4 to 13.9 ± 4.8 dB (p<0.001), possibly associated with lifestyle changes (e.g., smoking cessation, antioxidant and zinc supplementation). The mean retinal sensitivities of points within and close to the abnormal FAF were 9.9 and 11.7 dB, respectively, which were significantly lower than the 14.0 dB of the points distant from the abnormal FAF. Conclusion In Japanese patients, patchy and focally increased patterns predominated in the abnormal FAF. The retinal sensitivity was lower close to/within the abnormal FAF. FAF and microperimetry are useful to assess macular function before development of neovascular AMD or geographic atrophy.

Original languageEnglish
Article numbere0213161
JournalPloS one
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

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Macular Degeneration
Zinc
Japan
Antioxidants
eyes
photographs
Geographic Atrophy
observational studies
Smoking Cessation
atrophy
genetic background
Visual Acuity
lifestyle
Observational Studies
macular degeneration
Life Style
zinc
Prospective Studies
antioxidants
gender

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yasukawaid, T., Mori, R., Sawa, M., Shinojima, A., Hara, C., Sekiryu, T., ... Gomi, F. (2019). Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan. PloS one, 14(2), [e0213161]. https://doi.org/10.1371/journal.pone.0213161

Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan. / Yasukawaid, Tsutomu; Mori, Ryusaburo; Sawa, Miki; Shinojima, Ari; Hara, Chikako; Sekiryu, Tetsuju; Oshima, Yuji; Saito, Masaaki; Sugano, Yukinori; Kato, Aki; Ashikari, Masayuki; Hirano, Yoshio; Asato, Hitomi; Nakamura, Mayumi; Matsunoid, Kiyoshi; Kuno, Noriyuki; Kimura, Erika; Nishiyama, Takeshi; Yuzawa, Mitsuko; Ishibashi, Tatsuro; Ogura, Yuichiro; Iida, Tomohiro; Gomi, Fumi.

In: PloS one, Vol. 14, No. 2, e0213161, 01.02.2019.

Research output: Contribution to journalArticle

Yasukawaid, T, Mori, R, Sawa, M, Shinojima, A, Hara, C, Sekiryu, T, Oshima, Y, Saito, M, Sugano, Y, Kato, A, Ashikari, M, Hirano, Y, Asato, H, Nakamura, M, Matsunoid, K, Kuno, N, Kimura, E, Nishiyama, T, Yuzawa, M, Ishibashi, T, Ogura, Y, Iida, T & Gomi, F 2019, 'Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan', PloS one, vol. 14, no. 2, e0213161. https://doi.org/10.1371/journal.pone.0213161
Yasukawaid, Tsutomu ; Mori, Ryusaburo ; Sawa, Miki ; Shinojima, Ari ; Hara, Chikako ; Sekiryu, Tetsuju ; Oshima, Yuji ; Saito, Masaaki ; Sugano, Yukinori ; Kato, Aki ; Ashikari, Masayuki ; Hirano, Yoshio ; Asato, Hitomi ; Nakamura, Mayumi ; Matsunoid, Kiyoshi ; Kuno, Noriyuki ; Kimura, Erika ; Nishiyama, Takeshi ; Yuzawa, Mitsuko ; Ishibashi, Tatsuro ; Ogura, Yuichiro ; Iida, Tomohiro ; Gomi, Fumi. / Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan. In: PloS one. 2019 ; Vol. 14, No. 2.
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author = "Tsutomu Yasukawaid and Ryusaburo Mori and Miki Sawa and Ari Shinojima and Chikako Hara and Tetsuju Sekiryu and Yuji Oshima and Masaaki Saito and Yukinori Sugano and Aki Kato and Masayuki Ashikari and Yoshio Hirano and Hitomi Asato and Mayumi Nakamura and Kiyoshi Matsunoid and Noriyuki Kuno and Erika Kimura and Takeshi Nishiyama and Mitsuko Yuzawa and Tatsuro Ishibashi and Yuichiro Ogura and Tomohiro Iida and Fumi Gomi",
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T1 - Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan

AU - Yasukawaid, Tsutomu

AU - Mori, Ryusaburo

AU - Sawa, Miki

AU - Shinojima, Ari

AU - Hara, Chikako

AU - Sekiryu, Tetsuju

AU - Oshima, Yuji

AU - Saito, Masaaki

AU - Sugano, Yukinori

AU - Kato, Aki

AU - Ashikari, Masayuki

AU - Hirano, Yoshio

AU - Asato, Hitomi

AU - Nakamura, Mayumi

AU - Matsunoid, Kiyoshi

AU - Kuno, Noriyuki

AU - Kimura, Erika

AU - Nishiyama, Takeshi

AU - Yuzawa, Mitsuko

AU - Ishibashi, Tatsuro

AU - Ogura, Yuichiro

AU - Iida, Tomohiro

AU - Gomi, Fumi

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Purpose Abnormal fundus autofluorescence (FAF) potentially precedes onset of late age-related macular degeneration (AMD) in Caucasian patients. Many differences exist between Asian and Caucasian patients regarding AMD types and severity, gender, and genetic backgrounds. We investigated the characteristics of abnormal FAF and retinal sensitivity in the fellow eyes of Japanese patients with unilateral neovascular AMD. Methods Sixty-six patients with unilateral neovascular AMD and abnormal FAF in the fellow eye were enrolled in this multicenter, prospective, observational study. The best-corrected visual acuity, fundus photographs, FAF images, and retinal sensitivity on microperimetry were measured periodically for 12 months. The FAF images were classified into eight patterns based on the International Fundus Autofluorescence Classification Group. The points measured by microperimetry were superimposed onto the FAF images and fundus photographs and classified as "within," "close," and "distant," based on the distance from the abnormal FAF and other findings. The relationship between the location of the baseline abnormal FAF and retinal sensitivity was investigated. Results In Japanese patients, patchy (33.3%) and focally increased (30.3%) patterns predominated in the abnormal FAF. Intermediate-to-large drusen was associated predominantly with hyperfluorescence and hypofluorescence. Neovascular AMD developed within 1 year in six (9.1%) eyes, the mean baseline retinal sensitivity of which was 12.8 ± 4.7 dB, significantly (p<0.002) lower than the other eyes. In 44 of the other 60 eyes, microperimetry was measurable at baseline and month 12 and the mean retinal sensitivity improved significantly from 13.5 ± 4.4 to 13.9 ± 4.8 dB (p<0.001), possibly associated with lifestyle changes (e.g., smoking cessation, antioxidant and zinc supplementation). The mean retinal sensitivities of points within and close to the abnormal FAF were 9.9 and 11.7 dB, respectively, which were significantly lower than the 14.0 dB of the points distant from the abnormal FAF. Conclusion In Japanese patients, patchy and focally increased patterns predominated in the abnormal FAF. The retinal sensitivity was lower close to/within the abnormal FAF. FAF and microperimetry are useful to assess macular function before development of neovascular AMD or geographic atrophy.

AB - Purpose Abnormal fundus autofluorescence (FAF) potentially precedes onset of late age-related macular degeneration (AMD) in Caucasian patients. Many differences exist between Asian and Caucasian patients regarding AMD types and severity, gender, and genetic backgrounds. We investigated the characteristics of abnormal FAF and retinal sensitivity in the fellow eyes of Japanese patients with unilateral neovascular AMD. Methods Sixty-six patients with unilateral neovascular AMD and abnormal FAF in the fellow eye were enrolled in this multicenter, prospective, observational study. The best-corrected visual acuity, fundus photographs, FAF images, and retinal sensitivity on microperimetry were measured periodically for 12 months. The FAF images were classified into eight patterns based on the International Fundus Autofluorescence Classification Group. The points measured by microperimetry were superimposed onto the FAF images and fundus photographs and classified as "within," "close," and "distant," based on the distance from the abnormal FAF and other findings. The relationship between the location of the baseline abnormal FAF and retinal sensitivity was investigated. Results In Japanese patients, patchy (33.3%) and focally increased (30.3%) patterns predominated in the abnormal FAF. Intermediate-to-large drusen was associated predominantly with hyperfluorescence and hypofluorescence. Neovascular AMD developed within 1 year in six (9.1%) eyes, the mean baseline retinal sensitivity of which was 12.8 ± 4.7 dB, significantly (p<0.002) lower than the other eyes. In 44 of the other 60 eyes, microperimetry was measurable at baseline and month 12 and the mean retinal sensitivity improved significantly from 13.5 ± 4.4 to 13.9 ± 4.8 dB (p<0.001), possibly associated with lifestyle changes (e.g., smoking cessation, antioxidant and zinc supplementation). The mean retinal sensitivities of points within and close to the abnormal FAF were 9.9 and 11.7 dB, respectively, which were significantly lower than the 14.0 dB of the points distant from the abnormal FAF. Conclusion In Japanese patients, patchy and focally increased patterns predominated in the abnormal FAF. The retinal sensitivity was lower close to/within the abnormal FAF. FAF and microperimetry are useful to assess macular function before development of neovascular AMD or geographic atrophy.

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