Fungal cleavage of thioether bond found in Yperite

Noriyuki Itoh, Michiko Yoshida, Tadashi Miyamoto, Hirofumi Ichinose, Hiroyuki Wariishi, Hiroo Tanaka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The degradation of thiodiglycol (I) and benzyl sulfide (II) was attempted using Coriolus versicolor and Tyromyces palustris to investigate the potential ability of basidiomycetes to degrade Yperite (bis(2-chloroethyl) sulfide), a mass-produced and stored chemical. warfare agent, I was very rapidly degraded by both fungi. The metabolic pathway of II was elucidated, showing that the initial step was the hydrolytic cleavage of the thioether bond to yield benzyl alcohol and benzyl mercaptan. Benzyl alcohol was further oxidized and finally mineralized. Benzyl mercaptan is reversibly converted to benzyl disulfide and also converted to benzyl alcohol. Finally, the effective degradation of bis(2-bromoethyl) sulfide strongly suggests that basidiomycete would be a potential tool for Yperite degradation.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalFEBS Letters
Volume412
Issue number2
DOIs
Publication statusPublished - Jul 28 1997

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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