Fusiform gyrus volume reduction in first-episode schizophrenia: A magnetic resonance imaging study

Chang Uk Lee, Martha E. Shenton, Dean F. Salisbury, Kiyoto Kasai, Toshiaki Onitsuka, Chandlee C. Dickey, Deborah Yurgelun-Todd, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley

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105 Citations (Scopus)

Abstract

Background: The fusiform gyrus (occipitotemporal gyrus) is thought to be critical for face recognition and may possibly be associated with impaired facial recognition and interpretation of facial expression in schizophrenia. Results of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging. Methods: High-spatial resolution magnetic resonance images were used to measure the gray matter volume of the fusiform gyrus in 22 patients with first-episode schizophrenia (first hospitalization), 20 with first-episode affective psychosis (mainly manic), and 24 control subjects. Results: Patients with first-episode schizophrenia had overall smaller relative volumes (absolute volume/intracranial contents) of fusiform gyrus gray matter compared with controls (9%) and patients with affective psychosis (7%). For the left fusiform gyrus, patients with schizophrenia showed an 11% reduction compared with controls and patients with affective psychosis. Right fusiform gyrus volume differed in patients with schizophrenia only compared with controls (8%). Conclusion: Schizophrenia is associated with a bilateral reduction in fusiform gyrus gray matter volume that is evident at the time of first hospitalization and is different from the presentation of affective psychosis.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalArchives of General Psychiatry
Volume59
Issue number9
DOIs
Publication statusPublished - Sep 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Lee, C. U., Shenton, M. E., Salisbury, D. F., Kasai, K., Onitsuka, T., Dickey, C. C., Yurgelun-Todd, D., Kikinis, R., Jolesz, F. A., & McCarley, R. W. (2002). Fusiform gyrus volume reduction in first-episode schizophrenia: A magnetic resonance imaging study. Archives of General Psychiatry, 59(9), 775-781. https://doi.org/10.1001/archpsyc.59.9.775