12 and Gα13 as key regulatory mediator in signal transduction

Research output: Contribution to journalArticle

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Abstract

It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalLife Sciences
Volume74
Issue number2-3
DOIs
Publication statusPublished - Dec 5 2003

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G12-G13 GTP-Binding Protein alpha Subunits
Rho Guanine Nucleotide Exchange Factors
Phospholipase D
Signal transduction
Monomeric GTP-Binding Proteins
Type C Phospholipases
Signal Transduction
Phosphotransferases
Chemical activation
Apoptosis
Proteins
Ion exchange

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

12 and Gα13 as key regulatory mediator in signal transduction. / Kurose, Hitoshi.

In: Life Sciences, Vol. 74, No. 2-3, 05.12.2003, p. 155-161.

Research output: Contribution to journalArticle

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