Gα12 and Gα13 as key regulatory mediator in signal transduction

Hitoshi Kurose

doi:10.1016/j.lfs.2003.09.003

Gα₁₂ and Gα₁₃ as key regulatory mediator in signal transduction

Hitoshi Kurose

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

It is generally thought that Gα₁₂ and Gα ₁₃-induced responses are exclusively mediated by small G protein Rho. However, Gα₁₂ and Gα₁₃ elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα₁₂ and Gα₁₃ interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα₁₂ and Gα₁₃ with these proteins has not fully established. I summarize the recent progress of Gα₁₂ and Gα₁₃-mediated signaling cascade.

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Life Sciences
Volume	74
Issue number	2-3
DOIs	https://doi.org/10.1016/j.lfs.2003.09.003
Publication status	Published - Dec 5 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/j.lfs.2003.09.003

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title = "Gα12 and Gα13 as key regulatory mediator in signal transduction",

abstract = "It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.",

author = "Hitoshi Kurose",

note = "Funding Information: The work presented in this article was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.",

year = "2003",

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N1 - Funding Information: The work presented in this article was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.

PY - 2003/12/5

Y1 - 2003/12/5

N2 - It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.

AB - It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.

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ER -

Gα₁₂ and Gα₁₃ as key regulatory mediator in signal transduction

Abstract

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