It is generally thought that Gα12 and Gα 13-induced responses are exclusively mediated by small G protein Rho. However, Gα12 and Gα13 elicit divergent cellular responses: phospholipase C-ε activation, phospholipase D activation, cytoskeletal change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Gα12 and Gα13 interact with several proteins and regulate their activities. However, physiological importance of the interaction of Gα12 and Gα13 with these proteins has not fully established. I summarize the recent progress of Gα12 and Gα13-mediated signaling cascade.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)