Gadolinium blocks mechano-electric transducer current in chick cochlear hair cells

Takashi Kimitsuki, Takashi Nakagawa, Kazutaka Hisashi, Shizuo Komune, Sohtaro Komiyama

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

We investigated the effects of gadolinium ion (Gd3+) on the mechano-electrical transduction (MET) current using a whole-cell patch electrode voltage clamp technique in dissociated cochlear hair cells of chicks. Gd3+ blocked the MET channel in a concentration- and voltage-dependent manner. At -50 mV, Gd3+ blocked the MET channel, with a Hill coefficient of 1.14 and a dissociation constant (K(D)) of 1.01 x 10-5 M. Adaptation of the MET current disappeared after the introduction of Gd3+, a change that may be due to a decrease in inward going MET currents, specifically the Ca2+ component.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalHearing Research
Volume101
Issue number1-2
DOIs
Publication statusPublished - Nov 1 1996

All Science Journal Classification (ASJC) codes

  • Sensory Systems

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