Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.

Tomomi Sumida, Keith A. Stubbs, Makoto Ito, Shigeyuki Yokoyama

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-β-N-acetylhexosaminidases but also other types of glycoside hydrolases.

Original languageEnglish
Pages (from-to)2607-2612
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number13
DOIs
Publication statusPublished - Apr 7 2012

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glucosides
Glycoside Hydrolases
Enzyme Inhibitors
inhibitors
enzymes
Enzymes
Structural analysis
enzyme inhibitors
X-Rays
X rays
structural analysis
methodology
x rays

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach. / Sumida, Tomomi; Stubbs, Keith A.; Ito, Makoto; Yokoyama, Shigeyuki.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 13, 07.04.2012, p. 2607-2612.

Research output: Contribution to journalArticle

Sumida, Tomomi ; Stubbs, Keith A. ; Ito, Makoto ; Yokoyama, Shigeyuki. / Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach. In: Organic and Biomolecular Chemistry. 2012 ; Vol. 10, No. 13. pp. 2607-2612.
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