Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement

T. Deguchi, N. Takeshita, T. A. Balam, Y. Fujiyoshi, T. Takano-Yamamoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalJournal of Dental Research
Volume82
Issue number9
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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