TY - JOUR
T1 - Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum
AU - Fatmawati, Sri
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
N1 - Funding Information:
We are thankful to Dr. Miyamoto for optical rotation measurement, to Mr. Matsumoto for HRESIMS measurement and Hitachi Scholarship Foundation - Japan, for postgraduate scholarship to S.F.
PY - 2010/12
Y1 - 2010/12
N2 - Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.
AB - Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.
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U2 - 10.1016/j.fitote.2010.06.025
DO - 10.1016/j.fitote.2010.06.025
M3 - Article
C2 - 20603199
AN - SCOPUS:78549231564
SN - 0367-326X
VL - 81
SP - 1033
EP - 1036
JO - Fitoterapia
JF - Fitoterapia
IS - 8
ER -