Ganoderic acids from ganoderma lucidum: Inhibitory activity of osteoclastic differentiation and structural criteria

Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Ryuichiro Kondo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalPlanta medica
Volume76
Issue number2
DOIs
Publication statusPublished - Jan 22 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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