Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl 3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC 50 of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC 50 of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3, 26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC 50 of 48.5 μg/ml (119.8 μM).

Original languageEnglish
Pages (from-to)1053-1055
Number of pages3
JournalPhytomedicine
Volume18
Issue number12
DOIs
Publication statusPublished - Sep 15 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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