Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test: Role of insulin in gastric motility

Masahiro Matsumoto, Rie Yoshimura, Hirotada Akiho, Naomi Higuchi, Kunihisa Kobayashi, Noriaki Matsui, Kentaro Taki, Hiroyuki Murao, Haruei Ogino, Kenji Kanayama, Yorinobu Sumida, Takahiro Mizutani, Kuniomi Honda, Shigetaka Yoshinaga, Soichi Itaba, Hiromi Muta, Naohiko Harada, Kazuhiko Nakamura, Ryoichi Takayanagi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13 C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13 C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13 CO 2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13 C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalJournal of gastroenterology
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

Fingerprint

Breath Tests
Gastric Emptying
Stomach
Insulin
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Diabetes Mellitus
octanoic acid
Carbon Monoxide
Sex Characteristics
Meals

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Matsumoto, M., Yoshimura, R., Akiho, H., Higuchi, N., Kobayashi, K., Matsui, N., ... Takayanagi, R. (2007). Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test: Role of insulin in gastric motility. Journal of gastroenterology, 42(6), 469-474. https://doi.org/10.1007/s00535-007-2031-2

Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test : Role of insulin in gastric motility. / Matsumoto, Masahiro; Yoshimura, Rie; Akiho, Hirotada; Higuchi, Naomi; Kobayashi, Kunihisa; Matsui, Noriaki; Taki, Kentaro; Murao, Hiroyuki; Ogino, Haruei; Kanayama, Kenji; Sumida, Yorinobu; Mizutani, Takahiro; Honda, Kuniomi; Yoshinaga, Shigetaka; Itaba, Soichi; Muta, Hiromi; Harada, Naohiko; Nakamura, Kazuhiko; Takayanagi, Ryoichi.

In: Journal of gastroenterology, Vol. 42, No. 6, 01.06.2007, p. 469-474.

Research output: Contribution to journalArticle

Matsumoto, M, Yoshimura, R, Akiho, H, Higuchi, N, Kobayashi, K, Matsui, N, Taki, K, Murao, H, Ogino, H, Kanayama, K, Sumida, Y, Mizutani, T, Honda, K, Yoshinaga, S, Itaba, S, Muta, H, Harada, N, Nakamura, K & Takayanagi, R 2007, 'Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test: Role of insulin in gastric motility', Journal of gastroenterology, vol. 42, no. 6, pp. 469-474. https://doi.org/10.1007/s00535-007-2031-2
Matsumoto, Masahiro ; Yoshimura, Rie ; Akiho, Hirotada ; Higuchi, Naomi ; Kobayashi, Kunihisa ; Matsui, Noriaki ; Taki, Kentaro ; Murao, Hiroyuki ; Ogino, Haruei ; Kanayama, Kenji ; Sumida, Yorinobu ; Mizutani, Takahiro ; Honda, Kuniomi ; Yoshinaga, Shigetaka ; Itaba, Soichi ; Muta, Hiromi ; Harada, Naohiko ; Nakamura, Kazuhiko ; Takayanagi, Ryoichi. / Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test : Role of insulin in gastric motility. In: Journal of gastroenterology. 2007 ; Vol. 42, No. 6. pp. 469-474.
@article{df67d36b0b2c4571a3b3797fe0e77e3a,
title = "Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test: Role of insulin in gastric motility",
abstract = "Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13 C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13 C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13 CO 2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13 C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.",
author = "Masahiro Matsumoto and Rie Yoshimura and Hirotada Akiho and Naomi Higuchi and Kunihisa Kobayashi and Noriaki Matsui and Kentaro Taki and Hiroyuki Murao and Haruei Ogino and Kenji Kanayama and Yorinobu Sumida and Takahiro Mizutani and Kuniomi Honda and Shigetaka Yoshinaga and Soichi Itaba and Hiromi Muta and Naohiko Harada and Kazuhiko Nakamura and Ryoichi Takayanagi",
year = "2007",
month = "6",
day = "1",
doi = "10.1007/s00535-007-2031-2",
language = "English",
volume = "42",
pages = "469--474",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "6",

}

TY - JOUR

T1 - Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test

T2 - Role of insulin in gastric motility

AU - Matsumoto, Masahiro

AU - Yoshimura, Rie

AU - Akiho, Hirotada

AU - Higuchi, Naomi

AU - Kobayashi, Kunihisa

AU - Matsui, Noriaki

AU - Taki, Kentaro

AU - Murao, Hiroyuki

AU - Ogino, Haruei

AU - Kanayama, Kenji

AU - Sumida, Yorinobu

AU - Mizutani, Takahiro

AU - Honda, Kuniomi

AU - Yoshinaga, Shigetaka

AU - Itaba, Soichi

AU - Muta, Hiromi

AU - Harada, Naohiko

AU - Nakamura, Kazuhiko

AU - Takayanagi, Ryoichi

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13 C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13 C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13 CO 2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13 C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.

AB - Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13 C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13 C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13 CO 2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13 C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.

UR - http://www.scopus.com/inward/record.url?scp=34447331420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447331420&partnerID=8YFLogxK

U2 - 10.1007/s00535-007-2031-2

DO - 10.1007/s00535-007-2031-2

M3 - Article

C2 - 17671762

AN - SCOPUS:34447331420

VL - 42

SP - 469

EP - 474

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - 6

ER -