TY - JOUR
T1 - Gastric emptying in diabetic patients by the 13C-octanoic acid breath test
T2 - Role of insulin in gastric motility
AU - Matsumoto, Masahiro
AU - Yoshimura, Rie
AU - Akiho, Hirotada
AU - Higuchi, Naomi
AU - Kobayashi, Kunihisa
AU - Matsui, Noriaki
AU - Taki, Kentaro
AU - Murao, Hiroyuki
AU - Ogino, Haruei
AU - Kanayama, Kenji
AU - Sumida, Yorinobu
AU - Mizutani, Takahiro
AU - Honda, Kuniomi
AU - Yoshinaga, Shigetaka
AU - Itaba, Soichi
AU - Muta, Hiromi
AU - Harada, Naohiko
AU - Nakamura, Kazuhiko
AU - Takayanagi, Ryoichi
PY - 2007/6
Y1 - 2007/6
N2 - Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13CO2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.
AB - Background: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. Methods: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100mg of 13C octanoic acid, and at 15-min intervals over a 300-min period postprandially. Results: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13CO2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. Conclusions: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.
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U2 - 10.1007/s00535-007-2031-2
DO - 10.1007/s00535-007-2031-2
M3 - Article
C2 - 17671762
AN - SCOPUS:34447331420
SN - 0944-1174
VL - 42
SP - 469
EP - 474
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
IS - 6
ER -
