Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test

Sakae Nohara; Masanori Iwase; Hirofumi Imoto; Nobuhiro Sasaki; Udai Nakamura; Yuji Uchizono; Saori Abe; Yasufumi Doi; Mitsuo Iida

doi:10.1016/j.jdiacomp.2005.07.007

Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using ¹³C-octanoic acid breath test

Sakae Nohara, Masanori Iwase, Hirofumi Imoto, Nobuhiro Sasaki, Udai Nakamura, Yuji Uchizono, Saori Abe, Yasufumi Doi, Mitsuo Iida

Department of Nephrology,Hypertension,and Strokology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Although the ¹³C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing ¹³C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.

Original language	English
Pages (from-to)	295-301
Number of pages	7
Journal	Journal of Diabetes and Its Complications
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.jdiacomp.2005.07.007
Publication status	Published - Sept 2006

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jdiacomp.2005.07.007

Cite this

Nohara, S., Iwase, M., Imoto, H., Sasaki, N., Nakamura, U., Uchizono, Y., Abe, S., Doi, Y., & Iida, M. (2006). Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using ¹³C-octanoic acid breath test. Journal of Diabetes and Its Complications, 20(5), 295-301. https://doi.org/10.1016/j.jdiacomp.2005.07.007

Nohara, S, Iwase, M, Imoto, H, Sasaki, N, Nakamura, U, Uchizono, Y, Abe, S, Doi, Y & Iida, M 2006, 'Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using ¹³C-octanoic acid breath test', Journal of Diabetes and Its Complications, vol. 20, no. 5, pp. 295-301. https://doi.org/10.1016/j.jdiacomp.2005.07.007

@article{da01dd6bb56d4e3d8fa343908417e420,

title = "Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test",

abstract = "Although the 13C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing 13C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.",

author = "Sakae Nohara and Masanori Iwase and Hirofumi Imoto and Nobuhiro Sasaki and Udai Nakamura and Yuji Uchizono and Saori Abe and Yasufumi Doi and Mitsuo Iida",

year = "2006",

month = sep,

doi = "10.1016/j.jdiacomp.2005.07.007",

language = "English",

volume = "20",

pages = "295--301",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test

AU - Nohara, Sakae

AU - Iwase, Masanori

AU - Imoto, Hirofumi

AU - Sasaki, Nobuhiro

AU - Nakamura, Udai

AU - Uchizono, Yuji

AU - Abe, Saori

AU - Doi, Yasufumi

AU - Iida, Mitsuo

PY - 2006/9

Y1 - 2006/9

N2 - Although the 13C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing 13C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.

AB - Although the 13C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing 13C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.

UR - http://www.scopus.com/inward/record.url?scp=33747883554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747883554&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2005.07.007

DO - 10.1016/j.jdiacomp.2005.07.007

M3 - Article

C2 - 16949516

AN - SCOPUS:33747883554

SN - 1056-8727

VL - 20

SP - 295

EP - 301

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 5

ER -