Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test

Sakae Nohara, Masanori Iwase, Hirofumi Imoto, Nobuhiro Sasaki, Udai Nakamura, Yuji Uchizono, Saori Abe, Yasufumi Doi, Mitsuo Iida

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Although the 13C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing 13C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalJournal of Diabetes and Its Complications
Volume20
Issue number5
DOIs
Publication statusPublished - Sep 2006

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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