Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action

Heying Zhou, Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Seino

Research output: Contribution to journalArticle

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Abstract

Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic β-cells upon ingestion of nutrients. Inhibition of GIP signaling prevents the onset of obesity and consequent insulin resistance induced by high-fat diet. In this study, we investigated the role of GIP in accumulation of triglycerides into adipocytes and in fat oxidation peripherally using insulin receptor substrate (IRS)-1-deficient mice and revealed that IRS-1-/- GIPR-/- mice exhibited both reduced adiposity and ameliorated insulin resistance. Furthermore, increased gene expression of CD36 and UCP2 in liver, and increased expression and enzyme activity of 3-hydroxyacyl-CoA dehydrogenase in skeletal muscle of IRS-1-/- GIPR-/- mice might contribute to the lower respiratory quotient and the higher fat oxidation in light phase. These results suggest that GIP plays a crucial role in switching from fat oxidation to fat accumulation under the diminished insulin action as a potential target for secondary prevention of insulin resistance.

Original languageEnglish
Pages (from-to)937-942
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume335
Issue number3
DOIs
Publication statusPublished - Sep 30 2005
Externally publishedYes

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Gastric Inhibitory Polypeptide
Adiposity
Insulin Receptor Substrate Proteins
Fats
Insulin
Insulin Resistance
Oxidation
3-Hydroxyacyl-CoA Dehydrogenase
High Fat Diet
Secondary Prevention
Adipocytes
Enzyme activity
Nutrition
Skeletal Muscle
Triglycerides
Gene expression
Obesity
Eating
Liver
Nutrients

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. / Zhou, Heying; Yamada, Yuichiro; Tsukiyama, Katsushi; Miyawaki, Kazumasa; Hosokawa, Masaya; Nagashima, Kazuaki; Toyoda, Kentaro; Naitoh, Rei; Mizunoya, Wataru; Fushiki, Tohru; Kadowaki, Takashi; Seino, Yutaka.

In: Biochemical and Biophysical Research Communications, Vol. 335, No. 3, 30.09.2005, p. 937-942.

Research output: Contribution to journalArticle

Zhou, H, Yamada, Y, Tsukiyama, K, Miyawaki, K, Hosokawa, M, Nagashima, K, Toyoda, K, Naitoh, R, Mizunoya, W, Fushiki, T, Kadowaki, T & Seino, Y 2005, 'Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action', Biochemical and Biophysical Research Communications, vol. 335, no. 3, pp. 937-942. https://doi.org/10.1016/j.bbrc.2005.07.164
Zhou, Heying ; Yamada, Yuichiro ; Tsukiyama, Katsushi ; Miyawaki, Kazumasa ; Hosokawa, Masaya ; Nagashima, Kazuaki ; Toyoda, Kentaro ; Naitoh, Rei ; Mizunoya, Wataru ; Fushiki, Tohru ; Kadowaki, Takashi ; Seino, Yutaka. / Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. In: Biochemical and Biophysical Research Communications. 2005 ; Vol. 335, No. 3. pp. 937-942.
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