Gender-specific associations of serum antibody to Porphyromonas gingivalis and inflammatory markers

Michiko Furuta, Yoshihiro Shimazaki, Shunichi Tanaka, Kenji Takeuchi, Yukie Shibata, Toru Takeshita, Fusanori Nishimura, Yoshihisa Yamashita

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3 Citations (Scopus)

Abstract

It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females.

Original languageEnglish
Article number897971
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - Jan 1 2015

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Porphyromonas gingivalis
Periodontal Diseases
C-Reactive Protein
Antibodies
Serum
Deterioration
Health
Health Status
Longitudinal Studies
Retrospective Studies
Regression Analysis
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Gender-specific associations of serum antibody to Porphyromonas gingivalis and inflammatory markers. / Furuta, Michiko; Shimazaki, Yoshihiro; Tanaka, Shunichi; Takeuchi, Kenji; Shibata, Yukie; Takeshita, Toru; Nishimura, Fusanori; Yamashita, Yoshihisa.

In: BioMed Research International, Vol. 2015, 897971, 01.01.2015.

Research output: Contribution to journalArticle

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