Gene delivery responding to PKA signal using bio-nanocapsule

Jun Oishi; Moeko Ijuin; Jeone Hun Kang; Joohee Jung; Takeshi Mori; Takuro Niidome; Katsuyuki Tanizawa; Kuroda Shun-Ichi; Yoshiki Katayama

Gene delivery responding to PKA signal using bio-nanocapsule

Jun Oishi, Moeko Ijuin, Jeone Hun Kang, Joohee Jung, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa, Kuroda Shun-Ichi, Yoshiki Katayama

Research output: Contribution to conference › Paper › peer-review

Abstract

We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA) and attempted to apply this system to living cell. On the other hand, Kuroda et al has established a gene and drug delivery using bio-nanocapsule (BNC) and the partcles are able to mediate efficient targeted gene delivery to cultured human hepatocytes and to human hepatoma cells in vitro and in vivo. To put our system to practical use, we attempt to combine our PKA responsive gene delivery system with BNC. In this study, we were successful to intracellular signal-responsive regulation of delivered gene-expression in hepatocytes using BNC.

Original language	English
Pages	5365-5366
Number of pages	2
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: Sept 20 2006 → Sept 22 2006

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	9/20/06 → 9/22/06

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

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title = "Gene delivery responding to PKA signal using bio-nanocapsule",

abstract = "We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA) and attempted to apply this system to living cell. On the other hand, Kuroda et al has established a gene and drug delivery using bio-nanocapsule (BNC) and the partcles are able to mediate efficient targeted gene delivery to cultured human hepatocytes and to human hepatoma cells in vitro and in vivo. To put our system to practical use, we attempt to combine our PKA responsive gene delivery system with BNC. In this study, we were successful to intracellular signal-responsive regulation of delivered gene-expression in hepatocytes using BNC.",

author = "Jun Oishi and Moeko Ijuin and Kang, {Jeone Hun} and Joohee Jung and Takeshi Mori and Takuro Niidome and Katsuyuki Tanizawa and Kuroda Shun-Ichi and Yoshiki Katayama",

year = "2006",

language = "English",

pages = "5365--5366",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - Gene delivery responding to PKA signal using bio-nanocapsule

AU - Oishi, Jun

AU - Ijuin, Moeko

AU - Kang, Jeone Hun

AU - Jung, Joohee

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Tanizawa, Katsuyuki

AU - Shun-Ichi, Kuroda

AU - Katayama, Yoshiki

PY - 2006

Y1 - 2006

N2 - We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA) and attempted to apply this system to living cell. On the other hand, Kuroda et al has established a gene and drug delivery using bio-nanocapsule (BNC) and the partcles are able to mediate efficient targeted gene delivery to cultured human hepatocytes and to human hepatoma cells in vitro and in vivo. To put our system to practical use, we attempt to combine our PKA responsive gene delivery system with BNC. In this study, we were successful to intracellular signal-responsive regulation of delivered gene-expression in hepatocytes using BNC.

AB - We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA) and attempted to apply this system to living cell. On the other hand, Kuroda et al has established a gene and drug delivery using bio-nanocapsule (BNC) and the partcles are able to mediate efficient targeted gene delivery to cultured human hepatocytes and to human hepatoma cells in vitro and in vivo. To put our system to practical use, we attempt to combine our PKA responsive gene delivery system with BNC. In this study, we were successful to intracellular signal-responsive regulation of delivered gene-expression in hepatocytes using BNC.

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UR - http://www.scopus.com/inward/citedby.url?scp=33846143562&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846143562

SP - 5365

EP - 5366

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Gene delivery responding to PKA signal using bio-nanocapsule

Abstract

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All Science Journal Classification (ASJC) codes

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