Gene delivery responding to PKA signal using bio-nanocapsule

Jun Oishi, Moeko Ijuin, Jeone Hun Kang, Joohee Jung, Takeshi Mori, Takuro Niidome, Katsuyuki Tanizawa, Kuroda Shun-Ichi, Yoshiki Katayama

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA) and attempted to apply this system to living cell. On the other hand, Kuroda et al has established a gene and drug delivery using bio-nanocapsule (BNC) and the partcles are able to mediate efficient targeted gene delivery to cultured human hepatocytes and to human hepatoma cells in vitro and in vivo. To put our system to practical use, we attempt to combine our PKA responsive gene delivery system with BNC. In this study, we were successful to intracellular signal-responsive regulation of delivered gene-expression in hepatocytes using BNC.

    Original languageEnglish
    Pages5365-5366
    Number of pages2
    Publication statusPublished - 2006
    Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
    Duration: Sep 20 2006Sep 22 2006

    Other

    Other55th Society of Polymer Science Japan Symposium on Macromolecules
    Country/TerritoryJapan
    CityToyama
    Period9/20/069/22/06

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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