Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma

Masakuni Fukuzumi, Hiroyuki Hamakawa, Akiko Onishi, Tomoki Sumida, Hioaki Tanioka

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10 Citations (Scopus)

Abstract

In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalCancer Letters
Volume161
Issue number2
DOIs
Publication statusPublished - Dec 20 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Fukuzumi, M., Hamakawa, H., Onishi, A., Sumida, T., & Tanioka, H. (2000). Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma. Cancer Letters, 161(2), 133-140. https://doi.org/10.1016/S0304-3835(00)00613-3