Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma

Masakuni Fukuzumi; Hiroyuki Hamakawa; Akiko Onishi; Tomoki Sumida; Hioaki Tanioka

doi:10.1016/S0304-3835(00)00613-3

Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma

Masakuni Fukuzumi, Hiroyuki Hamakawa, Akiko Onishi, Tomoki Sumida, Hioaki Tanioka

Maxillofacial Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.

Original language	English
Pages (from-to)	133-140
Number of pages	8
Journal	Cancer Letters
Volume	161
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00613-3
Publication status	Published - Dec 20 2000

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/S0304-3835(00)00613-3

Cite this

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abstract = "In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.",

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T1 - Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma

AU - Fukuzumi, Masakuni

AU - Hamakawa, Hiroyuki

AU - Onishi, Akiko

AU - Sumida, Tomoki

AU - Tanioka, Hioaki

PY - 2000/12/20

Y1 - 2000/12/20

N2 - In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.

AB - In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.

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Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma

Abstract

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