Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma

Haruhiko Kashiwazaki, Nur Mohammad Monsur Hassan, Jun Ichi Hamada, Tetsuya Moriuchi, Yutaka Yamazaki, Kanchu Tei, Yasunori Totsuka, Nobuo Inoue

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalOdontology
Volume96
Issue number1
DOIs
Publication statusPublished - Jul 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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    Kashiwazaki, H., Hassan, N. M. M., Hamada, J. I., Moriuchi, T., Yamazaki, Y., Tei, K., Totsuka, Y., & Inoue, N. (2008). Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma. Odontology, 96(1), 38-43. https://doi.org/10.1007/s10266-008-0084-1